pubmed-article:19477633 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C0677886 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C0679250 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C0021666 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C1423887 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C2346626 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C1514185 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:19477633 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:19477633 | pubmed:issue | 12 | lld:pubmed |
pubmed-article:19477633 | pubmed:dateCreated | 2009-7-28 | lld:pubmed |
pubmed-article:19477633 | pubmed:abstractText | Lin-28 and lin-28B are RNA-binding proteins which can block microRNA let-7 maturation and affect the differentiation and proliferation of embryonic stem cells. Lin-28 may also regulate the expression of insulin-like growth factor II (IGF-II). As one of the pluripotent factors involved in making induced pluripotent stem cells (iPS), lin-28 is considered a potential therapeutic target for cancer treatment. To further understand the role of lin-28 in cancer, we analysed the expression of lin-28 and its homologue lin-28B in tumour samples, and evaluated their associations with let-7a maturation, IGF-II expression, disease features and outcomes in 211 patients with primary epithelial ovarian cancer. The analysis showed that both lin-28 and lin-28B were positively correlated with primary and pre-let-7a-3; lin-28B, not lin-28, was inversely correlated with mature let-7a. A positive correlation was also observed between lin-28B and IGF-II expression, while no association was found between lin-28B and IGF-I or IGFBP-3. The study further demonstrated that lin-28B expression was associated with the risk of disease progression and death; patients with high lin-28B had shorter progression-free and overall survival than those with low lin-28B. These results seem to support the findings of recent in vitro experiments, showing that lin-28 blocks the process of let-7a maturation. Our study also suggests that lin-28B may promote ovarian cancer progression and serve as an unfavourable prognostic marker for the disease. The correlation between lin-28B and IGF-II indicates that the growth factor may mediate the effect of lin-28B on tumour growth. | lld:pubmed |
pubmed-article:19477633 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19477633 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19477633 | pubmed:language | eng | lld:pubmed |
pubmed-article:19477633 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19477633 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:19477633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19477633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19477633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19477633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19477633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19477633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19477633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19477633 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:19477633 | pubmed:month | Aug | lld:pubmed |
pubmed-article:19477633 | pubmed:issn | 1879-0852 | lld:pubmed |
pubmed-article:19477633 | pubmed:author | pubmed-author:KatsarosDiony... | lld:pubmed |
pubmed-article:19477633 | pubmed:author | pubmed-author:YuHerbertH | lld:pubmed |
pubmed-article:19477633 | pubmed:author | pubmed-author:PretiMarioM | lld:pubmed |
pubmed-article:19477633 | pubmed:author | pubmed-author:LuLingengL | lld:pubmed |
pubmed-article:19477633 | pubmed:author | pubmed-author:MenatoGuidoG | lld:pubmed |
pubmed-article:19477633 | pubmed:author | pubmed-author:WuYixingY | lld:pubmed |
pubmed-article:19477633 | pubmed:author | pubmed-author:de la... | lld:pubmed |
pubmed-article:19477633 | pubmed:author | pubmed-author:QianBiyunB | lld:pubmed |
pubmed-article:19477633 | pubmed:author | pubmed-author:Shaverdashvil... | lld:pubmed |
pubmed-article:19477633 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:19477633 | pubmed:volume | 45 | lld:pubmed |
pubmed-article:19477633 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:19477633 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:19477633 | pubmed:pagination | 2212-8 | lld:pubmed |
pubmed-article:19477633 | pubmed:dateRevised | 2011-3-30 | lld:pubmed |
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pubmed-article:19477633 | pubmed:year | 2009 | lld:pubmed |
pubmed-article:19477633 | pubmed:articleTitle | Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II. | lld:pubmed |
pubmed-article:19477633 | pubmed:affiliation | Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, 60 College Street, New Haven, CT 06520-8034, USA. | lld:pubmed |
pubmed-article:19477633 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:19477633 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
pubmed-article:19477633 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19477633 | lld:pubmed |