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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-5-29
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pubmed:abstractText |
The apoptosis-inducing ability of alpha-ethano bridged crinane alkaloids was investigated using natural and semi-synthetic derivatives uncovering novel structural requirements of this cytotoxic pharmacophore. An alpha-ethano bridge is required; an alpha- or beta-methoxy or hydroxyl H-bond acceptor are all tolerated at C-3; a small substituent (H, or OH) alone is tolerated at C-11; and a C-1 to C-2 double bond is shown to modulate, but is not a requirement for, apoptosis-inducing activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1934-578X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
483-8
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pubmed:meshHeading |
pubmed-meshheading:19475990-Amaryllidaceae Alkaloids,
pubmed-meshheading:19475990-Apoptosis,
pubmed-meshheading:19475990-Caspase 3,
pubmed-meshheading:19475990-Dose-Response Relationship, Drug,
pubmed-meshheading:19475990-Enzyme Activation,
pubmed-meshheading:19475990-Humans,
pubmed-meshheading:19475990-Hydrogenation,
pubmed-meshheading:19475990-Jurkat Cells,
pubmed-meshheading:19475990-Phenanthridines,
pubmed-meshheading:19475990-Plant Extracts,
pubmed-meshheading:19475990-Structure-Activity Relationship
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pubmed:year |
2009
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pubmed:articleTitle |
Structure activity studies on the crinane alkaloid apoptosis-inducing pharmacophore.
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pubmed:affiliation |
Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4M1, Canada. jmcnult@mcmaster.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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