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rdf:type |
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lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0039194,
umls-concept:C0042769,
umls-concept:C0151317,
umls-concept:C0205250,
umls-concept:C0220847,
umls-concept:C0376249,
umls-concept:C0400914,
umls-concept:C0442805,
umls-concept:C1332714,
umls-concept:C1412933
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pubmed:issue |
3
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pubmed:dateCreated |
2009-8-3
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pubmed:abstractText |
CD4+ T cell responses are impaired in chronic HCV infection. To determine factor(s) involved in CD4+ T cell dysregulation, we examined the effect of extracellular core on the alteration of CD4+ T cell responses and the cell surface level of core-binding protein, gC1qR on CD4+ T cells from acute HCV patients with resolved and chronic infection. During the acute phase of infection, the frequency of gC1qR+CD4+ T cells increased in both resolved and chronic HCV infection compared to healthy controls. Notably, 6 months later, the frequency of gC1qR+CD4+ T cells maintained elevated in chronic patients compared to that in resolved patients. In addition, TCR stimulation increased the frequency of gC1qR+CD4+ T cells, resulting in core-induced inhibition of T cell responses in both resolved and chronic patients. These results suggest that HCV infection expands gC1qR+CD4+ T cells, which increase the susceptibility to core-mediated immune dysregulation and facilitate the establishment of HCV persistency.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/C1QBP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis C Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/core protein p22, Hepatitis C virus
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1521-7035
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
401-11
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pubmed:dateRevised |
2011-1-24
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pubmed:meshHeading |
pubmed-meshheading:19473882-Acute Disease,
pubmed-meshheading:19473882-Adolescent,
pubmed-meshheading:19473882-Adult,
pubmed-meshheading:19473882-CD4 Lymphocyte Count,
pubmed-meshheading:19473882-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19473882-Carrier Proteins,
pubmed-meshheading:19473882-Cell Proliferation,
pubmed-meshheading:19473882-Cell Survival,
pubmed-meshheading:19473882-Female,
pubmed-meshheading:19473882-Hepatitis C,
pubmed-meshheading:19473882-Hepatitis C, Chronic,
pubmed-meshheading:19473882-Hepatitis C Antigens,
pubmed-meshheading:19473882-Humans,
pubmed-meshheading:19473882-Leukocytes, Mononuclear,
pubmed-meshheading:19473882-Lymphocyte Activation,
pubmed-meshheading:19473882-Male,
pubmed-meshheading:19473882-Middle Aged,
pubmed-meshheading:19473882-Mitochondrial Proteins,
pubmed-meshheading:19473882-Receptors, Antigen, T-Cell,
pubmed-meshheading:19473882-T-Lymphocyte Subsets,
pubmed-meshheading:19473882-Viral Core Proteins,
pubmed-meshheading:19473882-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection.
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pubmed:affiliation |
Beirne Carter Center for Immunology Research and Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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