Linked Life Data

19473700

Source:http://linkedlifedata.com/resource/pubmed/id/19473700

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
25
pubmed:dateCreated
2009-7-14
pubmed:abstractText
In order to assess the suitability of polymer tissue scaffolds for use in regenerative medicine, methods to characterise scaffolds are needed. This requires the scaffold's structure to be determined for which X-ray microscopic computed tomography (X-ray micro CT) is widely used. However, because scaffolds are generally made of materials with low X-ray attenuating properties the images produced are far from ideal, which makes distinguishing scaffold material from the pores within it a non-trivial process. This paper presents a method for generating computer-simulated scaffolds that resemble the form of foamed polymer tissue scaffolds. Virtual images of the scaffold are then produced via a simulated X-ray micro CT process enabling the effect of varying the key parameters in the imaging process to be investigated. Here this is assessed via the calculated porosity of the sample, this being a simple measure of a scaffold's properties. Results highlight the difficulties in using X-ray micro CT to characterise scaffolds constructed from materials with low X-ray attenuating properties and suggest strategies that may be adopted in order to improve the quality of the images produced.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1878-5905
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4233-46
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Generation and simulated imaging of pseudo-scaffolds to aid characterisation by X-ray micro CT.
pubmed:affiliation
Electrical Systems and Applied Optics Research Division, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK. david.morris@nottingham.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't