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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-6-9
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pubmed:abstractText |
Treatment options for metastatic renal cell carcinoma (RCC) are limited due to resistance to chemo- and radiotherapy. The development of small-molecule multikinase inhibitors has now opened novel treatment options. We evaluated the influence of the receptor tyrosine kinase inhibitor AEE788, applied alone or combined with the mammalian target of rapamycin (mTOR) inhibitor RAD001, on RCC cell adhesion and proliferation in vitro.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19473483-11078807,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19473483-Carcinoma, Renal Cell,
pubmed-meshheading:19473483-Cell Adhesion,
pubmed-meshheading:19473483-Cell Cycle,
pubmed-meshheading:19473483-Cell Line, Tumor,
pubmed-meshheading:19473483-Cell Proliferation,
pubmed-meshheading:19473483-Down-Regulation,
pubmed-meshheading:19473483-Drug Therapy, Combination,
pubmed-meshheading:19473483-Gene Expression,
pubmed-meshheading:19473483-Humans,
pubmed-meshheading:19473483-Protein Kinase Inhibitors,
pubmed-meshheading:19473483-Protein Kinases,
pubmed-meshheading:19473483-Purines,
pubmed-meshheading:19473483-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:19473483-Sirolimus,
pubmed-meshheading:19473483-TOR Serine-Threonine Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cells.
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pubmed:affiliation |
Klinik für Urologie und Kinderurologie, Zentrum der Chirurgie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany. EMEWeich@web.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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