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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-5-28
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pubmed:abstractText |
Hepatic stellate cells express all components of the renin-angiotensinogen (AGT) system and secrete active angiotensin II. Animal studies provided evidence that angiotensin II stimulates the accumulation of extracellular matrix by enhancing transforming growth factor beta1 production. A functional genetic alteration in the human AGT promoter (c.1-44G>A) has been linked to accelerated progression of fibrosis in hepatitis C virus infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1945-0257
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pubmed:author |
pubmed-author:BergThomasT,
pubmed-author:FitzCarolinC,
pubmed-author:HalangkJulianeJ,
pubmed-author:HinrichsenHolgerH,
pubmed-author:MuellerTobiasT,
pubmed-author:NeuhausPeterP,
pubmed-author:NeumannKonradK,
pubmed-author:PuhlGeroG,
pubmed-author:SarrazinChristophC,
pubmed-author:WiedenmannBertramB,
pubmed-author:WittHeikoH
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pubmed:issnType |
Electronic
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
407-14
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pubmed:meshHeading |
pubmed-meshheading:19473084-Adult,
pubmed-meshheading:19473084-Aged,
pubmed-meshheading:19473084-Aged, 80 and over,
pubmed-meshheading:19473084-Alleles,
pubmed-meshheading:19473084-Angiotensinogen,
pubmed-meshheading:19473084-Case-Control Studies,
pubmed-meshheading:19473084-Disease Progression,
pubmed-meshheading:19473084-Female,
pubmed-meshheading:19473084-Fibrosis,
pubmed-meshheading:19473084-Gene Frequency,
pubmed-meshheading:19473084-Genetic Variation,
pubmed-meshheading:19473084-Genotype,
pubmed-meshheading:19473084-Hepatic Stellate Cells,
pubmed-meshheading:19473084-Hepatitis C, Chronic,
pubmed-meshheading:19473084-Humans,
pubmed-meshheading:19473084-Linkage Disequilibrium,
pubmed-meshheading:19473084-Liver Diseases,
pubmed-meshheading:19473084-Liver Diseases, Alcoholic,
pubmed-meshheading:19473084-Male,
pubmed-meshheading:19473084-Middle Aged,
pubmed-meshheading:19473084-Risk Factors,
pubmed-meshheading:19473084-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Evaluation of angiotensinogen c.1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver diseases of various etiologies.
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pubmed:affiliation |
Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charité Universitätsmedizin Berlin, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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