Linked Life Data

19472170

Source:http://linkedlifedata.com/resource/pubmed/id/19472170

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-9-2
pubmed:abstractText
We present a two-fold study designed to elucidate the adhesion mechanism of human U937 monocytes on novel N-rich thin films deposited by plasma- and VUV photo-polymerisation, so-called "PVP:N" materials. It is shown that there exist sharply-defined ("critical") surface-chemical conditions that are necessary to induce cell adhesion. By comparing the film chemistries at the "critical" conditions, we demonstrate the dominant role of primary amines in the cell adhesion mechanism. Quantitative real-time RT-PCR experiments using U937 cells that had adhered to PVP:N materials for up to 24 h are presented. The adhesion induces a transient expression of cytokines, markers of macrophage activation, as well as a more sustained expression of PPAR gamma and ICAM-I.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1616-5195
pubmed:author
pubmed:issnType
Electronic
pubmed:day
9
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
911-21
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Adhesion of human U937 monocytes to nitrogen-rich organic thin films: novel insights into the mechanism of cellular adhesion.
pubmed:affiliation
Groupe de Recherche en Physique et Technologie des Couches Minces (GCM) and Department of Engineering Physics, Ecole Polytechnique de Montréal, P.O. Box 6079, Station Centre-Ville, Montréal QC H3C 3A7, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't