Linked Life Data

19469848

Source:http://linkedlifedata.com/resource/pubmed/id/19469848

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-5-27
pubmed:abstractText
Lateral temporal epilepsies are still a poorly studied group of conditions, covering lesional and nonlesional cases. Within nonlesional cases, autosomal dominant lateral temporal epilepsy (ADLTE) is a well-defined, albeit rare, condition characterized by onset in adolescence or early adulthood of lateral temporal seizures with prominent auditory auras sometimes triggered by external noises, normal conventional magnetic resonance imaging (MRI), good response to antiepileptic treatment, and overall benign outcome. The same phenotype is shared by sporadic and familial cases with complex inheritance. Mutations in the LGI1 gene are found in about 50% of ADLTE families and 2% of sporadic cases. LGI1 shows no homology with known ion channel genes. Recent findings suggest that LGI1 may exert multiple functions, but it is not known which of them is actually related to lateral temporal epilepsy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1528-1167
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
50 Suppl 5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-4
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Lateral temporal lobe epilepsies: clinical and genetic features.
pubmed:affiliation
Department of Neurosciences, Ospedale Bellaria, Bologna, Italy. Roberto.Michelucci@ausl.bo.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't