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pubmed-article:19468200pubmed:abstractTextCutaneous sarcoidosis may be a chronic disease with important morbidity requiring aggressive therapy. The efficacy of different anti-tumor necrosis factor alpha(anti-TNF-alpha) treatments in refractory cutaneous and systemic sarcoidosis has been reported previously. We report the first patient with chronic cutaneous sarcoidosis who responded to dose escalation of anti-TNF-alpha agents that have been ineffective at the standard dosage, illustrating that the optimal dosing regimen has still to be defined for this indication before considering difficult-to-treat patients as nonresponders. Our case report also illustrates that the fusion protein etanercept, even used at a high dosage, may be less effective for the treatment of cutaneous sarcoidosis than the monoclonal antibodies infliximab and adalimumab.lld:pubmed
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pubmed-article:19468200pubmed:authorpubmed-author:ThielenA-MAMlld:pubmed
pubmed-article:19468200pubmed:copyrightInfo2009 S. Karger AG, Basel.lld:pubmed
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pubmed-article:19468200pubmed:volume219lld:pubmed
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pubmed-article:19468200pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:19468200pubmed:year2009lld:pubmed
pubmed-article:19468200pubmed:articleTitleRefractory chronic cutaneous sarcoidosis responsive to dose escalation of TNF-alpha antagonists.lld:pubmed
pubmed-article:19468200pubmed:affiliationDermatology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland. anne-marie.thielen@hcuge.chlld:pubmed
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