Linked Life Data

19467834

Source:http://linkedlifedata.com/resource/pubmed/id/19467834

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-9-14
pubmed:abstractText
Ischemic reperfusion injury due to oxidative stress remains one of the challenging problems during cardiac surgeries. The imbalance in the production of free radicals and antioxidants in vivo determines the extent of oxidative stress. The use of antioxidants in cardioplegia has become an important strategy to salvage the myocardium from the attack of these radicals. The objective of this study was to analyze the cardioprotective effect of N-acetylcysteine (NAC) on early reperfusion injury in patients undergoing coronary artery bypass grafting using biochemical markers. Fifty-three patients with left ventricular ejection fraction >0.4 scheduled for coronary artery bypass grafting with cardiopulmonary bypass were selected and divided into two groups. The first group of patients (n=25) received isothermic cardioplegia alone, whereas the second group of patients (n=28) received cardioplegia enriched with NAC (50mg/kg body weight). The free radicals, antioxidants, cardiac troponin I, and hemodynamic and clinical properties of the patients were preoperatively and postoperatively evaluated at five different time intervals. Malondialdehyde level as a measure of free radicals was significantly lower in the NAC-enriched group during reperfusion (p<0.05) and after 12 hr (p<0.05) and 24hr (p<0.001) of surgery. All the antioxidants were elevated in the test group during the reperfusion period (p<0.01). A significant improvement (p=0.001) in the postoperative ejection fraction was noted in the test group. No significant differences were observed between the groups in the level of cardiac troponin I (p=not significant). The use of NAC in patients undergoing coronary artery bypass grafting using cardiopulmonary bypass decreased oxidative stress substantially. However, it did not lead to improvement in the level of cardiac troponin I, a marker of myocardial injury, in our study. Hence, the cardioprotective effect of NAC and the adaptation of the myocardium to oxidative stress should be extensively studied.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1615-5947
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
645-51
pubmed:meshHeading
pubmed-meshheading:19467834-Acetylcysteine, pubmed-meshheading:19467834-Antioxidants, pubmed-meshheading:19467834-Biological Markers, pubmed-meshheading:19467834-Cardiopulmonary Bypass, pubmed-meshheading:19467834-Cardiotonic Agents, pubmed-meshheading:19467834-Catalase, pubmed-meshheading:19467834-Coronary Artery Bypass, pubmed-meshheading:19467834-Double-Blind Method, pubmed-meshheading:19467834-Glutathione, pubmed-meshheading:19467834-Glutathione Peroxidase, pubmed-meshheading:19467834-Glutathione Reductase, pubmed-meshheading:19467834-Heart Arrest, Induced, pubmed-meshheading:19467834-Hemodynamics, pubmed-meshheading:19467834-Humans, pubmed-meshheading:19467834-Malondialdehyde, pubmed-meshheading:19467834-Middle Aged, pubmed-meshheading:19467834-Myocardial Reperfusion Injury, pubmed-meshheading:19467834-Oxidative Stress, pubmed-meshheading:19467834-Prospective Studies, pubmed-meshheading:19467834-Stroke Volume, pubmed-meshheading:19467834-Superoxide Dismutase, pubmed-meshheading:19467834-Time Factors, pubmed-meshheading:19467834-Treatment Outcome, pubmed-meshheading:19467834-Troponin I, pubmed-meshheading:19467834-Ventricular Function, Left
pubmed:articleTitle
Effect of N-acetylcysteine in attenuating ischemic reperfusion injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.
pubmed:affiliation
Department of Biochemistry, MMM Academy of Medical Sciences, Chennai, India. prabhu_bio@yahoo.com
pubmed:publicationType
Journal Article, Randomized Controlled Trial