Linked Life Data

19466710

Source:http://linkedlifedata.com/resource/pubmed/id/19466710

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2009-8-31
pubmed:abstractText
A facile synthesis method to produce monodisperse, biocompatible, lysine crosslinked mercaptoundecanoic acid (MUA) CdSe(0.25)Te(0.75)/CdS near-infrared (NIR) quantum dots and use them as probes to study their long term in vivo distribution, clearance, and toxicity is presented. Large signal enhancements are demonstrated by these quantum dots, which enables their use as efficient and sensitive probes for live-animal imaging. An important finding is that mice intravenously injected with approximately 10.5 mg kg(-1) of NIR QDs survive for more than three months without any apparent adverse effect to their health. Furthermore, it is determined that there is a significant reduction in the number of the QDs in the liver and spleen three months post injection. In addition, histological analysis of heart, kidney, liver, spleen, and lung tissue indicates that there are no acute toxic effects from these lysine cross-linked MUA NIR QDs. This study suggests that these NIR QDs can be potentially used for long-term targeted imaging and therapy studies in vivo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1613-6829
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1997-2004
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Biocompatible near-infrared quantum dots as ultrasensitive probes for long-term in vivo imaging applications.
pubmed:affiliation
Institute for Lasers, Photonics, and Biophotonics, Department of Chemistry, University at Buffalo-The State University of New York, Buffalo, NY 14260-4200, USA. kyong2@buffalo.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural