Source:http://linkedlifedata.com/resource/pubmed/id/19466545
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2010-3-18
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| pubmed:abstractText |
The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-gamma-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions -667G>T, -148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 -148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1573-2568
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| pubmed:author |
pubmed-author:CheongHyun SubHS,
pubmed-author:CheongJae YounJY,
pubmed-author:ChoBo YoungBY,
pubmed-author:ChoSung WonSW,
pubmed-author:KimJin HongJH,
pubmed-author:KimmKuchanK,
pubmed-author:LeeJung AJA,
pubmed-author:LeeKee MyungKM,
pubmed-author:OhBermseokB,
pubmed-author:ParkByung LaeBL,
pubmed-author:ShinHyoung DooHD,
pubmed-author:ShinSung JaeSJ
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
55
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1113-9
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| pubmed:meshHeading |
pubmed-meshheading:19466545-Adult,
pubmed-meshheading:19466545-Aged,
pubmed-meshheading:19466545-Alleles,
pubmed-meshheading:19466545-Carrier State,
pubmed-meshheading:19466545-Chromosome Mapping,
pubmed-meshheading:19466545-Confidence Intervals,
pubmed-meshheading:19466545-Female,
pubmed-meshheading:19466545-Genes, Recessive,
pubmed-meshheading:19466545-Genotype,
pubmed-meshheading:19466545-Haplotypes,
pubmed-meshheading:19466545-Hepatitis B,
pubmed-meshheading:19466545-Humans,
pubmed-meshheading:19466545-Immunogenetic Phenomena,
pubmed-meshheading:19466545-Interleukin-18,
pubmed-meshheading:19466545-Linkage Disequilibrium,
pubmed-meshheading:19466545-Male,
pubmed-meshheading:19466545-Middle Aged,
pubmed-meshheading:19466545-Odds Ratio,
pubmed-meshheading:19466545-Polymorphism, Single Nucleotide,
pubmed-meshheading:19466545-Prospective Studies,
pubmed-meshheading:19466545-Remission, Spontaneous,
pubmed-meshheading:19466545-Republic of Korea,
pubmed-meshheading:19466545-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:19466545-Young Adult
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Association of interleukin-18 gene polymorphisms with hepatitis B virus clearance.
|
| pubmed:affiliation |
Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, San-5 Wonchon-Dong, Youngtong-ku, Suwon, 442-721, South Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|