Source:http://linkedlifedata.com/resource/pubmed/id/19465749
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2009-8-21
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pubmed:abstractText |
Owing to the rarity of adrenocortical carcinoma (ACC) no prognostic markers have been established beyond stage and resection status. Accelerated glycolysis is a characteristic feature of cancer cells and in a variety of tumour entities key factors in glucose metabolism like glucose transporter 1 and 3 (GLUT1 and -3), transketolase like-1 enzyme (TKTL1) and pyruvate kinase type M2 (M2-PK) are overexpressed and of prognostic value. Therefore, we investigated the role of these factors in ACC. Immunohistochemical analysis was performed on tissue microarrays of paraffin-embedded tissue samples from 167 ACCs, 15 adrenal adenomas and 4 normal adrenal glands. Expression was correlated with baseline parameters and clinical outcome. GLUT1 and -3 were expressed in 33 and 17% of ACC samples respectively, but in none of the benign tumours or normal adrenals glands. By contrast, TKTL1 and M2-PK were detectable in all benign tissues and the vast majority of ACCs. GLUT1 expression was strongly associated with prognosis in univariate and multivariate analysis (P<0.01), whereas GLUT3, TKTL1 and M2-PK did not correlate with clinical outcome. Patients with strong GLUT1 staining showed a considerably higher overall mortality (hazard ratio (HR) 6.34 (95% confidence interval 3.10-12.90) compared with patients with no GLUT1 staining. When analysing patients in their early stages and advanced disease separately, similar results were obtained. HR for survival was 5.31 (1.80-15.62) in patients with metastatic ACC and in patients after radical resection the HR for disease-free survival was 6.10 (2.16-16.94). In conclusion, GLUT1 is a highly promising stage-independent, prognostic marker in ACC.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1479-6821
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pubmed:author |
pubmed-author:AdamPatrickP,
pubmed-author:AllolioBrunoB,
pubmed-author:FassnachtMartinM,
pubmed-author:FenskeWiebkeW,
pubmed-author:HahnerStefanieS,
pubmed-author:JohanssenSarahS,
pubmed-author:Müller-HermelinkHans-KonradHK,
pubmed-author:MorcosMichaelM,
pubmed-author:SchmidtMelanieM,
pubmed-author:VölkerHans-UllrichHU,
pubmed-author:WortmannSebastianS
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
919-28
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pubmed:meshHeading |
pubmed-meshheading:19465749-Adrenal Cortex Neoplasms,
pubmed-meshheading:19465749-Adrenocortical Carcinoma,
pubmed-meshheading:19465749-Adult,
pubmed-meshheading:19465749-Aged,
pubmed-meshheading:19465749-Female,
pubmed-meshheading:19465749-Glucose,
pubmed-meshheading:19465749-Glucose Transporter Type 1,
pubmed-meshheading:19465749-Humans,
pubmed-meshheading:19465749-Male,
pubmed-meshheading:19465749-Middle Aged,
pubmed-meshheading:19465749-Neoplasm Staging,
pubmed-meshheading:19465749-Prognosis,
pubmed-meshheading:19465749-Tumor Markers, Biological
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pubmed:year |
2009
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pubmed:articleTitle |
Glucose transporter GLUT1 expression is an stage-independent predictor of clinical outcome in adrenocortical carcinoma.
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pubmed:affiliation |
Endocrine and Diabetic Unit, Department of Internal Medicine I, University Hospital of Würzburg, Josef-Schneider-Strasse 2, D-97080 Würzburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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