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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-5-25
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pubmed:abstractText |
Long-term results of surgical vessel reconstruction are compromised by restenosis caused by neointimal hyperplasia. Recent studies suggest that reduced cyclic guanosine monophosphate signaling is associated with neointima formation. In a rat model of endarterectomy, we investigated the effect of pharmacologic inhibition of cyclic guanosine monophosphate degradation on neointima formation by using the selective phosphodiesterase-5 inhibitor vardenafil.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-685X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1508-14
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19464472-Actins,
pubmed-meshheading:19464472-Animals,
pubmed-meshheading:19464472-Carotid Artery, Common,
pubmed-meshheading:19464472-Carotid Stenosis,
pubmed-meshheading:19464472-Cyclic GMP,
pubmed-meshheading:19464472-Endarterectomy, Carotid,
pubmed-meshheading:19464472-Hyperplasia,
pubmed-meshheading:19464472-Imidazoles,
pubmed-meshheading:19464472-Immunohistochemistry,
pubmed-meshheading:19464472-Male,
pubmed-meshheading:19464472-Phosphodiesterase 5 Inhibitors,
pubmed-meshheading:19464472-Phosphodiesterase Inhibitors,
pubmed-meshheading:19464472-Piperazines,
pubmed-meshheading:19464472-Rats,
pubmed-meshheading:19464472-Rats, Sprague-Dawley,
pubmed-meshheading:19464472-Recurrence,
pubmed-meshheading:19464472-Sulfones,
pubmed-meshheading:19464472-Transforming Growth Factor beta1,
pubmed-meshheading:19464472-Triazines,
pubmed-meshheading:19464472-Tunica Intima
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pubmed:year |
2009
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pubmed:articleTitle |
Selective phosphodiesterase-5 inhibition reduces neointimal hyperplasia in rat carotid arteries after surgical endarterectomy.
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pubmed:affiliation |
Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany. hirschbergkristof@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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