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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1991-12-3
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pubmed:abstractText |
In the yeast Saccharomyces cerevisiae, as in other eukaryotes, some regions of the genome have a much higher rate of meiotic recombination than others. We show below that the binding of the RAP1 protein to a site upstream of the HIS4 gene is necessary for a high rate of meiotic (but not mitotic) recombination at this locus. A mutation in the RAP1 binding site at HIS4 results in a decrease in recombination; overproduction of RAP1 causes an increase in recombination at HIS4 above wild-type levels.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-17246436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-17247336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-17248549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-1840557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-1849855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-1904543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-1986228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-1990267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-1990280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-2185891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-2537472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-2546083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-2645056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-2655930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-2656680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-2697465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-3221399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-3275867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-3295867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-3303332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-3315231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-3402730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-3464968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-388424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-6094015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-6096014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946399-7049842
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:geneSymbol |
HIS4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9755-9
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:1946399-Base Sequence,
pubmed-meshheading:1946399-Binding Sites,
pubmed-meshheading:1946399-DNA, Fungal,
pubmed-meshheading:1946399-GTP-Binding Proteins,
pubmed-meshheading:1946399-Gene Conversion,
pubmed-meshheading:1946399-Genes, Fungal,
pubmed-meshheading:1946399-Histidine,
pubmed-meshheading:1946399-Meiosis,
pubmed-meshheading:1946399-Mitosis,
pubmed-meshheading:1946399-Molecular Sequence Data,
pubmed-meshheading:1946399-Oligonucleotides,
pubmed-meshheading:1946399-Recombination, Genetic,
pubmed-meshheading:1946399-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1946399-Saccharomyces cerevisiae,
pubmed-meshheading:1946399-rap GTP-Binding Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.
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pubmed:affiliation |
Department of Biology, University of North Carolina, Chapel Hill 27599-3280.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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