|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004927,
umls-concept:C0006104,
umls-concept:C0015733,
umls-concept:C0016633,
umls-concept:C0028884,
umls-concept:C0035696,
umls-concept:C0087140,
umls-concept:C0205263,
umls-concept:C0449432,
umls-concept:C0449774,
umls-concept:C0916295,
umls-concept:C1179435,
umls-concept:C1280500,
umls-concept:C1517676,
umls-concept:C1521751,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1555903,
umls-concept:C1705248
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2009-5-25
|
|
pubmed:abstractText |
Predator odors, which are non-intrusive and naturalistic stressors of high ethological relevance, were used to study the neurobiology of innate fear in rodents. The present study investigates behavioral effects and the induction of c-fos mRNA in adult male predator naive mice caused by acute exposure to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), a component of the fox feces odor. On the behavioral level, TMT potently increased unconditioned freezing and decreased non-defensive grooming behavior. With quantitative real time PCR we established a strong TMT-induced activation in the bed nucleus of the stria terminalis (BNST) (eight-fold increase, p<0.016) and in the ventral olfactory bulb (two-fold increase, p<0.036). In contrast, no significant TMT-induced c-fos induction could be observed in the dorsal olfactory bulb or in the amygdala. Our results display robust fear responses of GAD67-GFP knock-in mice exposed to TMT and suggest that the ventral olfactory bulb and the BNST are strongly activated during the elicitation of fear through predator odor in these transgenic mice.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,5-dihydro-2,4,5-trimethylthiazolin...,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate decarboxylase 1
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1872-7549
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
14
|
|
pubmed:volume |
202
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
218-24
|
|
pubmed:meshHeading |
pubmed-meshheading:19463704-Amygdala,
pubmed-meshheading:19463704-Animals,
pubmed-meshheading:19463704-Behavior, Animal,
pubmed-meshheading:19463704-Brain,
pubmed-meshheading:19463704-Feces,
pubmed-meshheading:19463704-Foxes,
pubmed-meshheading:19463704-Freezing Reaction, Cataleptic,
pubmed-meshheading:19463704-Gene Knock-In Techniques,
pubmed-meshheading:19463704-Glutamate Decarboxylase,
pubmed-meshheading:19463704-Green Fluorescent Proteins,
pubmed-meshheading:19463704-Grooming,
pubmed-meshheading:19463704-Male,
pubmed-meshheading:19463704-Mice,
pubmed-meshheading:19463704-Mice, Inbred C57BL,
pubmed-meshheading:19463704-Mice, Transgenic,
pubmed-meshheading:19463704-Odors,
pubmed-meshheading:19463704-Olfactory Bulb,
pubmed-meshheading:19463704-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:19463704-RNA, Messenger,
pubmed-meshheading:19463704-Septal Nuclei,
pubmed-meshheading:19463704-Thiazoles
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Behavioral effects and pattern of brain c-fos mRNA induced by 2,5-dihydro-2,4,5-trimethylthiazoline, a component of fox feces odor in GAD67-GFP knock-in C57BL/6 mice.
|
|
pubmed:affiliation |
Institute of Anatomy, University of Magdeburg, D-39120 Magdeburg, Germany. k.janitzky@gmx.de
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
