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rdf:type |
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lifeskim:mentions |
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0039195,
umls-concept:C0085358,
umls-concept:C0597551,
umls-concept:C0682458,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1515655,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
21
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pubmed:dateCreated |
1991-12-3
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pubmed:abstractText |
The generation of antiviral cytotoxic T lymphocytes (CTLs) is a critical component of the immune response to viral infections. A safe and nontoxic vaccine for AIDS would optimally use a carrier-free synthetic peptide immunogen containing only components of HIV necessary for induction of protective immune responses. We report that hybrid synthetic peptides containing either a HIV envelope gp120 T-cell determinant (T1) or the envelope gp41 fusion domain (F) N-terminal to HIV CTL determinants are capable of priming murine CD8+, major histocompatibility complex class I-restricted anti-HIV CTLs in vivo. These data demonstrate that carrier-free, nonderivatized synthetic peptides can be used in vivo to induce anti-HIV CTL responses.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-1692084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-1698859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-1700435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-1700756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-1703322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-1824801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-1848698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-1978928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-1992491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2046762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2182912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2184369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2392685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2420472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2435562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2438696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2443853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2449694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2450351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2452443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2452447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2454471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2455389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2469721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2479705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2480595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2541505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2586621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2586628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2771954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2787356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2841610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2895317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-2969774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-3259143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-3285042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-3298467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-3496970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-3587367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1946358-3918115
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9448-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1946358-Amino Acid Sequence,
pubmed-meshheading:1946358-Animals,
pubmed-meshheading:1946358-Antigens, CD8,
pubmed-meshheading:1946358-H-2 Antigens,
pubmed-meshheading:1946358-HIV Antigens,
pubmed-meshheading:1946358-HIV Envelope Protein gp120,
pubmed-meshheading:1946358-HIV-1,
pubmed-meshheading:1946358-Immunologic Memory,
pubmed-meshheading:1946358-Major Histocompatibility Complex,
pubmed-meshheading:1946358-Mice,
pubmed-meshheading:1946358-Mice, Inbred BALB C,
pubmed-meshheading:1946358-Mice, Inbred C57BL,
pubmed-meshheading:1946358-Molecular Sequence Data,
pubmed-meshheading:1946358-Peptides,
pubmed-meshheading:1946358-T-Lymphocytes, Cytotoxic
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pubmed:year |
1991
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pubmed:articleTitle |
Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides.
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