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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-3
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pubmed:abstractText |
Alterations in FOXC1 dosage lead to a spectrum of highly penetrant, ocular anterior segment dysgenesis phenotypes. The most serious outcome is the development of glaucoma, which occurs in 50% to 75% of patients. Therefore, the need to identify specific pathways and genes that interact with FOXC1 to promote glaucoma is great. In this study, the authors investigated the loss of foxC1 in the zebrafish to characterize phenotypes and gene interactions that may impact glaucoma pathogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1552-5783
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5026-34
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pubmed:meshHeading |
pubmed-meshheading:19458328-Animals,
pubmed-meshheading:19458328-Basement Membrane,
pubmed-meshheading:19458328-Biological Markers,
pubmed-meshheading:19458328-Endothelium, Vascular,
pubmed-meshheading:19458328-Eye,
pubmed-meshheading:19458328-Fluorescein Angiography,
pubmed-meshheading:19458328-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:19458328-Forkhead Transcription Factors,
pubmed-meshheading:19458328-Gene Expression,
pubmed-meshheading:19458328-Gene Knockout Techniques,
pubmed-meshheading:19458328-Gene Silencing,
pubmed-meshheading:19458328-In Situ Hybridization,
pubmed-meshheading:19458328-Laminin,
pubmed-meshheading:19458328-Lens, Crystalline,
pubmed-meshheading:19458328-Microscopy, Confocal,
pubmed-meshheading:19458328-Microscopy, Electron, Transmission,
pubmed-meshheading:19458328-Morphogenesis,
pubmed-meshheading:19458328-Ophthalmic Artery,
pubmed-meshheading:19458328-Zebrafish,
pubmed-meshheading:19458328-Zebrafish Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis.
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pubmed:affiliation |
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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