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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-8-13
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pubmed:abstractText |
Increased proinflammatory cytokines after myocardial infarction augment the progression of heart failure (HF) and are of prognostic significance. Recently, we demonstrated that increased proinflammatory cytokines in the brains of HF rats increased paraventricular nucleus (PVN) superoxide and down-regulated neuronal nitric oxide synthase (nNOS), contributing to sympathoexcitation. In this study, we explored the possible roles of brain proinflammatory cytokines and their effects on modulating PVN neurotransmitters in the exaggerated sympathetic activity in HF.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nos1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Pentoxifylline,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFR-Fc fusion protein,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
737-46
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pubmed:dateRevised |
2010-9-2
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pubmed:meshHeading |
pubmed-meshheading:19457890-Animals,
pubmed-meshheading:19457890-Brain,
pubmed-meshheading:19457890-Cytokines,
pubmed-meshheading:19457890-Heart Failure,
pubmed-meshheading:19457890-Immunoglobulin G,
pubmed-meshheading:19457890-Inflammation Mediators,
pubmed-meshheading:19457890-Kidney,
pubmed-meshheading:19457890-Male,
pubmed-meshheading:19457890-Neurotransmitter Agents,
pubmed-meshheading:19457890-Nitric Oxide Synthase,
pubmed-meshheading:19457890-Paraventricular Hypothalamic Nucleus,
pubmed-meshheading:19457890-Pentoxifylline,
pubmed-meshheading:19457890-RNA, Messenger,
pubmed-meshheading:19457890-Rats,
pubmed-meshheading:19457890-Rats, Sprague-Dawley,
pubmed-meshheading:19457890-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:19457890-Sympathetic Nervous System,
pubmed-meshheading:19457890-Tumor Necrosis Factor-alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Brain tumour necrosis factor-alpha modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure.
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pubmed:affiliation |
Department of Physiology, Shantou University Medical College, Shantou 515041, China. ymkang@lsu.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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