Linked Life Data

19457617

Source:http://linkedlifedata.com/resource/pubmed/id/19457617

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-9-30
pubmed:abstractText
Lung cancer in the older individual is an increasingly common problem faced by the oncologist. Elderly patients over 70 years account about 40% of lung cancer patients. Performance Status 2 patients represent a significantly high proportion of advanced non-small cell lung cancer (NSCLC) patients (30-40%) when population-based surveys are conducted. Thus, unfit older patients represent a significant proportion of advanced NSCLC patients, for whom specific prospective data are very scarce. Elderly cancer patients often present with medical and physiological challenges that make the selection of their optimal treatment daunting. Single-agent chemotherapy should be considered the standard treatment for unfit older patients with advanced NSCLC. Molecularly targeted therapies as erlotinib and gefitinib, if approved for use in the next future also in the first-line treatment of advanced NSCLC, may represent a valid alternative to single-agent chemotherapy for a large proportion of unfit older patients because of their more favourable safety profile. However, specific prospective investigation is absolutely warranted for this special population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1532-1967
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
517-21
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Management of unfit older patients with advanced NSCLC.
pubmed:affiliation
Division of Medical Oncology, S.G. Moscati Hospital, Contrada Amoretta - 83100, Avellino, Italy. cgridelli@libero.it
pubmed:publicationType
Journal Article, Review