rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
2010-2-1
|
pubmed:abstractText |
GD2/GM2 synthase is a key enzyme in the synthesis of GD2 and GM2 gangliosides found on the surface of neuroblastoma and small cell lung carcinoma (SCLC) cells. In neuroblastoma, persistent levels of GD2/GM2 synthase RNA in bone marrow (BM) following therapy portend poorer progression-free and overall survival. We conducted this study to determine if GD2/GM2 synthase RNA could be detected in SCLC cell lines and human tissues, and whether mRNA transcript levels corresponded with disease status.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1872-8332
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
67
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
216-20
|
pubmed:meshHeading |
pubmed-meshheading:19457569-Carcinoma, Small Cell,
pubmed-meshheading:19457569-Cell Line, Tumor,
pubmed-meshheading:19457569-Female,
pubmed-meshheading:19457569-Humans,
pubmed-meshheading:19457569-Lung Neoplasms,
pubmed-meshheading:19457569-Male,
pubmed-meshheading:19457569-Middle Aged,
pubmed-meshheading:19457569-N-Acetylgalactosaminyltransferases,
pubmed-meshheading:19457569-Neoplasm Recurrence, Local,
pubmed-meshheading:19457569-Pilot Projects,
pubmed-meshheading:19457569-Polymerase Chain Reaction,
pubmed-meshheading:19457569-RNA, Messenger,
pubmed-meshheading:19457569-Tumor Markers, Biological
|
pubmed:year |
2010
|
pubmed:articleTitle |
Analysis of GD2/GM2 synthase mRNA as a biomarker for small cell lung cancer.
|
pubmed:affiliation |
Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, 1275 York Ave., New York, NY, United States.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|