Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-6-22
pubmed:abstractText
Tamoxifen has been found to be neuroprotective in both transient and permanent experimental ischemic stroke. However, it remains unknown whether this agent shows a similar beneficial effect after spinal cord injury (SCI), and what are its underlying mechanisms. In this study, we investigated the efficacy of tamoxifen treatment in attenuating SCI-induced pathology. Blood-spinal cord barrier (BSCB) permeability, tissue edema formation, microglial activation, neuronal cell death and myelin loss were determined in rats subjected to spinal cord contusion. The results showed that tamoxifen, administered at 30 min post-injury, significantly decreased interleukin-1beta (IL-1beta) production induced by microglial activation, alleviated the amount of Evans blue leakage and edema formation. In addition, tamoxifen treatment clearly reduced the number of apoptotic neurons post-SCI. The myelin loss and the increase in production of myelin-associated axonal growth inhibitors were also found to be significantly attenuated at day 3 post-injury. Furthermore, rats treated with tamoxifen scored much higher on the locomotor rating scale after SCI than did vehicle-treated rats, suggesting improved functional outcome after SCI. Together, these results demonstrate that tamoxifen provides neuroprotective effects for treatment of SCI-related pathology and disability, and is therefore a potential neuroprotectant for human spinal cord injury therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11b, http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta, http://linkedlifedata.com/resource/pubmed/chemical/Luxol Fast Blue MBS, http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Myelin-Associated Glycoprotein, http://linkedlifedata.com/resource/pubmed/chemical/Nogo protein, http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments, http://linkedlifedata.com/resource/pubmed/chemical/Phosphopyruvate Hydratase, http://linkedlifedata.com/resource/pubmed/chemical/Tamoxifen, http://linkedlifedata.com/resource/pubmed/chemical/interleukin-1beta (163-171)
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1471-4159
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1658-67
pubmed:meshHeading
pubmed-meshheading:19457130-Animals, pubmed-meshheading:19457130-Antigens, CD11b, pubmed-meshheading:19457130-Apoptosis, pubmed-meshheading:19457130-Behavior, Animal, pubmed-meshheading:19457130-Blood-Brain Barrier, pubmed-meshheading:19457130-Disease Models, Animal, pubmed-meshheading:19457130-Double-Blind Method, pubmed-meshheading:19457130-Edema, pubmed-meshheading:19457130-Estrogen Antagonists, pubmed-meshheading:19457130-Gene Expression Regulation, pubmed-meshheading:19457130-In Situ Nick-End Labeling, pubmed-meshheading:19457130-Indoles, pubmed-meshheading:19457130-Inflammation, pubmed-meshheading:19457130-Interleukin-1beta, pubmed-meshheading:19457130-Male, pubmed-meshheading:19457130-Myelin Proteins, pubmed-meshheading:19457130-Myelin Sheath, pubmed-meshheading:19457130-Myelin-Associated Glycoprotein, pubmed-meshheading:19457130-Peptide Fragments, pubmed-meshheading:19457130-Phosphopyruvate Hydratase, pubmed-meshheading:19457130-Rats, pubmed-meshheading:19457130-Rats, Sprague-Dawley, pubmed-meshheading:19457130-Recovery of Function, pubmed-meshheading:19457130-Spinal Cord Injuries, pubmed-meshheading:19457130-Tamoxifen, pubmed-meshheading:19457130-Time Factors
pubmed:year
2009
pubmed:articleTitle
Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats.
pubmed:affiliation
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't