Linked Life Data

19456897

Source:http://linkedlifedata.com/resource/pubmed/id/19456897

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-8-28
pubmed:abstractText
Aim: Acetylation is emerging as a crucial post-translational modification in controlling the expression of eukaryotic genes. Histone deacetylase (HDAC) inhibitors, developed as antitumor reagents, have recently exhibited novel anti-inflammatory properties. In the present study, the influence of HDAC inhibitor on hepatic injury during sepsis was investigated. Methods: Trichostatin A (TSA), a potent HDAC-specific inhibitor, was administrated to mice with cecal ligation and puncture (CLP)-induced sepsis. The degree of hepatic injury and inflammation was assessed subsequently. Results: The results indicated that TSA effectively protected liver from CLP-induced injury as evidenced by decreased serum aminotransferases (alanine and aspartate) levels, reduced malondialdehyde (MDA) content in liver homogenates and improved histological damage. The dampened liver injury was accompanied by lower myeloperoxidase (MPO) activity and suppressed expression of intercellular adhesion molecule-1 (ICAM-1) in liver tissue. In addition, the concentrations of both interleukin (IL)-6 and IL-10 in serum or hepatic homogenates were also decreased in TSA-treated septic mice. Conclusion: These data indicate that HDAC inhibitor TSA effectively attenuates liver injury during sepsis and these effects seem to rely on reduced inflammatory mediator production. These findings suggest that novel anti-inflammatory drugs targeting HDAC might offer promising therapeutic intervention for controlling the dysregulated inflammation.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Sep
pubmed:issn
1386-6346
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
931-8
pubmed:year
2009
pubmed:articleTitle
Protective effects of trichostatin A on liver injury in septic mice.
pubmed:affiliation
Department of Pathophysiology, Chongqing Medical University, Chongqing, China.
pubmed:publicationType
Journal Article