Linked Life Data

19456401

Source:http://linkedlifedata.com/resource/pubmed/id/19456401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-5-21
pubmed:abstractText
In order to study the expression of the gonadotropin alpha subunit and beta subunit [follicle-stimulating hormone (FSH)-beta and luteinizing hormone (LH)-beta] cDNAs in the hermaphroditic fish Kryptolebias marmoratus, we cloned these genes and analyzed their modulatory effects in the brain/pituitary tissue after exposure to 17beta estradiol (E2), tamoxifen (TMX), and octyphenol. Gonadotropin beta subunit (FSH-beta and LH-beta) showed E2-dependent upregulation in most hermaphrodites, whereas TMX did not show elevated expression. Octyphenol also showed a similar effect of upregulation on FSH-beta expression but not for the LH-beta gene. These results suggest that the expression of FSH-beta and LH-beta in K. marmoratus is associated with their expression on endocrine-disrupting chemicals in this species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1163
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
508-11
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Expression of gonadotropin alpha, follicle-stimulating hormone beta, and luteinizing hormone beta genes of the hermaphroditic fish Kryptolebias marmoratus exposed to octylphenol, 17beta estradiol, and tamoxifen.
pubmed:affiliation
Department of Molecular and Environmental Bioscience, Graduate School, Hanyang University, Seoul, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't