Source:http://linkedlifedata.com/resource/pubmed/id/19455600
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2009-12-28
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pubmed:abstractText |
In order to evaluate the contribution of 19 serotonin-related genes to the susceptibility to migraine in a Spanish population we performed a case-control association study of 122 single nucleotide polymorphisms (SNPs), selected according to genetic coverage parameters, in 528 migraine patients -308 with migraine without aura (MO) and 220 with migraine with aura (MA)- and 528 sex-matched migraine-free controls. The single-marker analysis identified nominal associations with the migraine phenotype or with the MO or MA subtypes. The multiple-marker analysis revealed risk haplotypes in three genes that remained significantly associated with migraine after correction by permutations. Two-marker risk haplotypes were identified in the HTR2B (rs16827801T-rs10194776G) and MAOA (rs3027400G-rs2072743C) genes conferring susceptibility to MO, and a four-marker haplotype in DDC was specific of MA (rs2329340A-rs11974297C-rs2044859T-rs11761683G). The present study supports the involvement of HTR2B and MAOA genes in the genetic predisposition to MO, while DDC might confer susceptibility to MA. These results suggest a differential involvement of serotonin-related genes in the genetic background of MO and MA.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1552-485X
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pubmed:author | |
pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
153B
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
177-84
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pubmed:meshHeading |
pubmed-meshheading:19455600-Case-Control Studies,
pubmed-meshheading:19455600-Dopa Decarboxylase,
pubmed-meshheading:19455600-Epistasis, Genetic,
pubmed-meshheading:19455600-Genome-Wide Association Study,
pubmed-meshheading:19455600-Humans,
pubmed-meshheading:19455600-Migraine Disorders,
pubmed-meshheading:19455600-Monoamine Oxidase,
pubmed-meshheading:19455600-Polymorphism, Single Nucleotide,
pubmed-meshheading:19455600-Receptor, Serotonin, 5-HT2B,
pubmed-meshheading:19455600-Serotonin,
pubmed-meshheading:19455600-Spain
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pubmed:year |
2010
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pubmed:articleTitle |
Association study of the serotoninergic system in migraine in the Spanish population.
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pubmed:affiliation |
Grup de Recerca en Neurologia Infantil i Psiquiatria Genètica, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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