rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
8
|
pubmed:dateCreated |
2009-7-14
|
pubmed:abstractText |
Type 1 diabetes is a proinflammatory state characterised by increased levels of circulating biomarkers of inflammation and monocyte activity. We have shown increased Toll-like receptor 2 (TLR2) and TLR4 expression and signalling in monocytes from type 1 diabetic patients. Several endogenous ligands of TLR2 and TLR4 have been identified; however, there is a paucity of data on levels of these endogenous ligands in diabetes. Thus, the aim of this study was to examine circulating levels of exogenous/endogenous ligands of TLR2 and TLR4 in type 1 diabetic patients and to compare these with the levels in matched healthy controls.
|
pubmed:grant |
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1432-0428
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
52
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1665-8
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:19455302-Adult,
pubmed-meshheading:19455302-Diabetes Mellitus, Type 1,
pubmed-meshheading:19455302-Female,
pubmed-meshheading:19455302-Gene Expression Regulation,
pubmed-meshheading:19455302-Hemoglobin A, Glycosylated,
pubmed-meshheading:19455302-Humans,
pubmed-meshheading:19455302-Hyperglycemia,
pubmed-meshheading:19455302-Hypoglycemic Agents,
pubmed-meshheading:19455302-Inflammation,
pubmed-meshheading:19455302-Insulin,
pubmed-meshheading:19455302-Male,
pubmed-meshheading:19455302-Middle Aged,
pubmed-meshheading:19455302-Reference Values,
pubmed-meshheading:19455302-Toll-Like Receptor 2,
pubmed-meshheading:19455302-Toll-Like Receptor 4,
pubmed-meshheading:19455302-Young Adult
|
pubmed:year |
2009
|
pubmed:articleTitle |
Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes.
|
pubmed:affiliation |
Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|