Linked Life Data

19455265

Source:http://linkedlifedata.com/resource/pubmed/id/19455265

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-5-20
pubmed:abstractText
The choice of appropriate animal models for the initial in vivo testing of potential anticonvulsant compounds is one of the most important steps in the successful search for new antiepileptic drugs. The purpose of this paper is to describe the most important aspects to take into account when performing the maximal electroshock seizure (MES) test in the routine laboratory screening of new antiepileptics: the conventional and threshold MES test experimental procedures, the factors affecting experimental data (laboratory conditions, administration vehicles and drug formulations, time after drug administration, and stimulus duration and site of stimulation) and the assessment of anticonvulsant activity are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0379-0355
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved.
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-6
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic drugs.
pubmed:affiliation
Laboratory of Pharmacology, Faculty of Pharmacy, Coimbra University, Coimbra, Portugal.
pubmed:publicationType
Journal Article