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rdf:type |
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lifeskim:mentions |
umls-concept:C0023895,
umls-concept:C0025241,
umls-concept:C0030705,
umls-concept:C0205054,
umls-concept:C0268381,
umls-concept:C0332281,
umls-concept:C0871261,
umls-concept:C1504389,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
7
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pubmed:dateCreated |
2009-7-2
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pubmed:abstractText |
High-dose melphalan chemotherapy and autologous peripheral blood stem cell transplantation has been shown to result in durable hematologic response and prolonged overall survival in systemic AL amyloidosis. In this retrospective study, we evaluated clinical and hematologic responses in 69 patients with predominant liver involvement who were treated with high-dose intravenous melphalan and autologous stem cell transplantation from 1998 to 2006. Nine patients (13%) died from treatment-related mortality, similar to patients without hepatic involvement. The overall survival was 81% at one year and 61% at five years, by Kaplan-Meier estimates. A hematologic complete response was achieved by 53% (31/58) of patients at one year. A hepatic response occurred in 57% (33/58) at one year after high-dose intravenous melphalan and autologous stem cell transplantation and 63% (19/30) at two years after high-dose intravenous melphalan and autologous stem cell transplantation. In conclusion, hepatic disease improves in almost 2/3 patients treated with high-dose intravenous melphalan and autologous stem cell transplantation who have a complete or partial hematologic response to treatment.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-11329232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-14530778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-14734330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-15044325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-15070667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-15572585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-16044444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-16862166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-17272986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-17673601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-17855669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-17968685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-17968927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-1916751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-3389383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-6353084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-7878478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-8629674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-9110907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-9302305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19454500-9920856
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1592-8721
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1029-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19454500-Adult,
pubmed-meshheading:19454500-Aged,
pubmed-meshheading:19454500-Amyloidosis,
pubmed-meshheading:19454500-Female,
pubmed-meshheading:19454500-Humans,
pubmed-meshheading:19454500-Liver,
pubmed-meshheading:19454500-Liver Diseases,
pubmed-meshheading:19454500-Male,
pubmed-meshheading:19454500-Melphalan,
pubmed-meshheading:19454500-Middle Aged,
pubmed-meshheading:19454500-Myeloablative Agonists,
pubmed-meshheading:19454500-Retrospective Studies,
pubmed-meshheading:19454500-Stem Cell Transplantation,
pubmed-meshheading:19454500-Treatment Outcome
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pubmed:year |
2009
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pubmed:articleTitle |
Hepatic response after high-dose melphalan and stem cell transplantation in patients with AL amyloidosis associated liver disease.
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pubmed:affiliation |
Department of Medicine, Boston University School of Medicine, Boston University School of Public Health, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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