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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-9-1
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pubmed:abstractText |
Celiac disease (CD) is a common chronic disorder of the small intestine, resulting from aberrant cellular responses to gluten peptides, and often remains undiagnosed. It is a complex genetic disorder, although 95% of the patients carry the risk heterodimer human leukocyte antigen (HLA)-DQ2. Genome-wide association studies on CD have identified 9 non-HLA loci that also contribute to CD risk, most of which are shared with other immune-related diseases. Our aim is to predict the genetic risk for CD using HLA and non-HLA risk alleles.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1528-0012
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pubmed:author |
pubmed-author:BardellaMaria TeresaMT,
pubmed-author:BarisaniDonatellaD,
pubmed-author:FuJingyuanJ,
pubmed-author:McManusRossR,
pubmed-author:NolteIlja MIM,
pubmed-author:RomanosJihaneJ,
pubmed-author:TrynkaGosiaG,
pubmed-author:WijmengaCiscaC,
pubmed-author:ZhernakovaAlexandraA,
pubmed-author:van DiemenCleo CCC,
pubmed-author:van HeelDavid ADA
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pubmed:issnType |
Electronic
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
834-40, 840.e1-3
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pubmed:meshHeading |
pubmed-meshheading:19454285-Adolescent,
pubmed-meshheading:19454285-Adult,
pubmed-meshheading:19454285-Aged,
pubmed-meshheading:19454285-Aged, 80 and over,
pubmed-meshheading:19454285-Alleles,
pubmed-meshheading:19454285-Celiac Disease,
pubmed-meshheading:19454285-Child,
pubmed-meshheading:19454285-Child, Preschool,
pubmed-meshheading:19454285-Europe,
pubmed-meshheading:19454285-Female,
pubmed-meshheading:19454285-Genetic Markers,
pubmed-meshheading:19454285-Genetic Predisposition to Disease,
pubmed-meshheading:19454285-Genotype,
pubmed-meshheading:19454285-HLA-DQ Antigens,
pubmed-meshheading:19454285-Humans,
pubmed-meshheading:19454285-Infant,
pubmed-meshheading:19454285-Male,
pubmed-meshheading:19454285-Middle Aged,
pubmed-meshheading:19454285-Polymorphism, Single Nucleotide,
pubmed-meshheading:19454285-Risk Factors,
pubmed-meshheading:19454285-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease.
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pubmed:affiliation |
Department of Genetics, University Medical Centre of Groningen, University of Groningen, Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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