Linked Life Data

19452252

Source:http://linkedlifedata.com/resource/pubmed/id/19452252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-6-2
pubmed:abstractText
Based on the presence of the tumor-specific over-expression of Plk1 (polo-like kinases) in various malignancies, we examined Plk1 expression in nine cases of reactive follicular hyperplasia (RFH), 42 of diffuse large B cell lymphoma (DLBCL), 16 of follicular lymphoma (FL), and 10 of nasal NK/T lymphoma. There was no significant difference in the Plk1-positive cell percentage between RFH and DLBCL. The Plk1-positive cell percentage ranged from 6 to 20% with a median of 12.9% in DLBCL. In FL, Plk1-positivity was at most 7%. Plk1-positivity in nasal NK/T cell lymphoma (4.7-14.1% with a median of 9.2%) was significantly higher than that of FL and tended to be lower than DLBCL (p < 0.001, p = 0.05, respectively). Although a strong correlation between positive cell percentages for Plk1 and Ki-67 in these three lymphomas specified Plk1 as a proliferation marker (r = 0.83-0.91), the Plk1-positive cell percentage relative to the other proliferation markers tended to be particularly low in nasal NK/T cell lymphoma. In 41 cases of DLBCL, the positive cell percentages of Plk1 and Ki-67 were both correlated with overall survival. The 4-year overall survival rates by Kaplan-Meier analysis for Plk1-negative and positive patients were 80 and 38%, respectively (p = 0.02).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1865-3774
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
673-8
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:19452252-Biological Markers, pubmed-meshheading:19452252-Cell Cycle Proteins, pubmed-meshheading:19452252-Cell Proliferation, pubmed-meshheading:19452252-Gene Expression Regulation, Neoplastic, pubmed-meshheading:19452252-Humans, pubmed-meshheading:19452252-Ki-67 Antigen, pubmed-meshheading:19452252-Lymphoma, Extranodal NK-T-Cell, pubmed-meshheading:19452252-Lymphoma, Follicular, pubmed-meshheading:19452252-Lymphoma, Large B-Cell, Diffuse, pubmed-meshheading:19452252-Lymphoma, Non-Hodgkin, pubmed-meshheading:19452252-Neoplasm Proteins, pubmed-meshheading:19452252-Nose Neoplasms, pubmed-meshheading:19452252-Prognosis, pubmed-meshheading:19452252-Protein-Serine-Threonine Kinases, pubmed-meshheading:19452252-Proto-Oncogene Proteins, pubmed-meshheading:19452252-Survival Analysis
pubmed:year
2009
pubmed:articleTitle
Absence of tumor-specific over-expression of Polo-like kinase 1 (Plk1) in major non-Hodgkin lymphoma and relatively low expression of Plk1 in nasal NK/T cell lymphoma.
pubmed:affiliation
Department of Internal Medicine, Division of Hematology, Juntendo University School of Medicine, Tokyo, Japan.
pubmed:publicationType
Journal Article