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rdf:type |
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lifeskim:mentions |
umls-concept:C0001807,
umls-concept:C0012854,
umls-concept:C0013879,
umls-concept:C0017337,
umls-concept:C0017638,
umls-concept:C0162638,
umls-concept:C0178638,
umls-concept:C1514485,
umls-concept:C1515075,
umls-concept:C1549649,
umls-concept:C1705914,
umls-concept:C2349209
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pubmed:issue |
10
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pubmed:dateCreated |
2009-5-19
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pubmed:abstractText |
We have investigated whether the folate supplementation could be used to limit the aggressiveness of glioma through the DNA remethylation because (a) the cancer genome is characterized by a low level of DNA methylation (or 5-methylcytosine, 5 mC); and (b) folate is the main generator of S-adenosyl-methionine, the methyl donor molecule in the DNA methylation reaction catalyzed by the DNA methyltranferases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/BCL2L2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BIRC5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA (Cytosine-5-)-Methyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Modification Methylases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA methyltransferase 3A,
http://linkedlifedata.com/resource/pubmed/chemical/DNA methyltransferase 3B,
http://linkedlifedata.com/resource/pubmed/chemical/Dacarbazine,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Apoptosis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MGMT protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sp1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sp3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor BB,
http://linkedlifedata.com/resource/pubmed/chemical/temozolomide
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3519-29
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19451595-Aged,
pubmed-meshheading:19451595-Apoptosis,
pubmed-meshheading:19451595-Apoptosis Regulatory Proteins,
pubmed-meshheading:19451595-Cell Line, Tumor,
pubmed-meshheading:19451595-Cell Proliferation,
pubmed-meshheading:19451595-DNA (Cytosine-5-)-Methyltransferase,
pubmed-meshheading:19451595-DNA Methylation,
pubmed-meshheading:19451595-DNA Modification Methylases,
pubmed-meshheading:19451595-DNA Repair Enzymes,
pubmed-meshheading:19451595-Dacarbazine,
pubmed-meshheading:19451595-Dietary Supplements,
pubmed-meshheading:19451595-Folic Acid,
pubmed-meshheading:19451595-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19451595-Glioma,
pubmed-meshheading:19451595-Humans,
pubmed-meshheading:19451595-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:19451595-Microtubule-Associated Proteins,
pubmed-meshheading:19451595-Middle Aged,
pubmed-meshheading:19451595-Neoplasm Invasiveness,
pubmed-meshheading:19451595-Platelet-Derived Growth Factor,
pubmed-meshheading:19451595-Protein Binding,
pubmed-meshheading:19451595-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:19451595-Sp1 Transcription Factor,
pubmed-meshheading:19451595-Sp3 Transcription Factor,
pubmed-meshheading:19451595-Survival Analysis,
pubmed-meshheading:19451595-Tumor Suppressor Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Folate supplementation limits the aggressiveness of glioma via the remethylation of DNA repeats element and genes governing apoptosis and proliferation.
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pubmed:affiliation |
Institut National de la Sante et de la Recherche Medicale U892, Centre de Recherche en Cancérologie, Equipe Apoptose et Progression Tumorale, Nantes, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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