Source:http://linkedlifedata.com/resource/pubmed/id/19451314
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
978
|
| pubmed:dateCreated |
2009-5-19
|
| pubmed:abstractText |
The aim of this study was to investigate the outcome in 556 patients with locally advanced nasopharyngeal carcinomas treated by radiation therapy alone. We observed 556 patients with stage T3-4 and N0-3 carcinoma who were treated by conventional radiotherapy alone between January and December 1999. The total dose delivered to the nasopharynx was 66-80 Gy over 6.5-8 weeks and to the neck lymph nodes 60-70 Gy over 6-7 weeks. The 5-year actuarial overall survival rate (OS) reached 66.41%. The OS was higher among stage T3 patients than among stage T4 patients (69.12% vs 58.96%, p = 0.0359). Among patients with stage N0, N1, N2 and N3 disease, the OS was 73.98%, 65.96%, 57.58% and 29.39%, respectively (p = 0.0009). Differences in disease-free survival, locoregional control rate and metastasis-free survival rate among each N stage were statistically significant, although this was not true of differences between stage T3 and T4 disease. Multivariate analysis showed that gender, age, T stage and N stage were significant prognostic factors for 5-year overall survival, disease-free survival, locoregional control and metastasis-free survival. We found that N stage is the dominant prognostic indicator for patients with locally advanced nasopharyngeal carcinoma receiving conventional radiation therapy alone, and that T stage was only a secondary correlative factor.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1748-880X
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
82
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
452-8
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| pubmed:meshHeading |
pubmed-meshheading:19451314-Adolescent,
pubmed-meshheading:19451314-Adult,
pubmed-meshheading:19451314-Aged,
pubmed-meshheading:19451314-Disease-Free Survival,
pubmed-meshheading:19451314-Female,
pubmed-meshheading:19451314-Humans,
pubmed-meshheading:19451314-Lymphatic Metastasis,
pubmed-meshheading:19451314-Male,
pubmed-meshheading:19451314-Middle Aged,
pubmed-meshheading:19451314-Multivariate Analysis,
pubmed-meshheading:19451314-Nasopharyngeal Neoplasms,
pubmed-meshheading:19451314-Neoplasm Staging,
pubmed-meshheading:19451314-Prognosis,
pubmed-meshheading:19451314-Radiation Dosage,
pubmed-meshheading:19451314-Radiotherapy,
pubmed-meshheading:19451314-Retrospective Studies,
pubmed-meshheading:19451314-Treatment Outcome,
pubmed-meshheading:19451314-Young Adult
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Treatment results and late complications of 556 patients with locally advanced nasopharyngeal carcinoma treated with radiotherapy alone.
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| pubmed:affiliation |
Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, People's Republic of China.
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| pubmed:publicationType |
Journal Article
|