| pubmed-article:19450557 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19450557 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:19450557 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:19450557 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:19450557 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:19450557 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19450557 | pubmed:dateCreated | 2009-6-15 | lld:pubmed |
| pubmed-article:19450557 | pubmed:abstractText | Biomechanical stress modulates vascular tone, vascular remodelling and the spatial localisation of atherosclerotic plaques. Inflammatory cytokines, such as TNF-alpha, regulate expression of genes that impair the function of endothelial cells. This study investigates the combinatory effect of different biomechanical stresses and TNF-alpha on the expression of endothelial anti- and prothrombotic genes. Human umbilical vein endothelial cells were exposed to TNF-alpha and different levels of static/pulsatile tensile stress or shear stress. The response in endothelial cells to TNF-alpha was not modulated by tensile stress. However, shear stress was a more potent stimulus. Shear stress counteracted the cytokine-induced expression of VCAM-1, and the cytokine-suppressed expression of thrombomodulin and eNOS. Shear stress and TNF-alpha additively induced PAI-1, whereas shear stress blocked the cytokine effect on t-PA and u-PA. A flow profile characterized by high laminar shear stress seems to render the endothelial cell more resistant to inflammatory stress. | lld:pubmed |
| pubmed-article:19450557 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19450557 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19450557 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19450557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19450557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19450557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19450557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19450557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19450557 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19450557 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19450557 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:19450557 | pubmed:author | pubmed-author:KarlssonLL | lld:pubmed |
| pubmed-article:19450557 | pubmed:author | pubmed-author:BergeSS | lld:pubmed |
| pubmed-article:19450557 | pubmed:author | pubmed-author:GliseKK | lld:pubmed |
| pubmed-article:19450557 | pubmed:author | pubmed-author:JernSS | lld:pubmed |
| pubmed-article:19450557 | pubmed:author | pubmed-author:UlfhammerEE | lld:pubmed |
| pubmed-article:19450557 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19450557 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:19450557 | pubmed:volume | 385 | lld:pubmed |
| pubmed-article:19450557 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19450557 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19450557 | pubmed:pagination | 314-8 | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:meshHeading | pubmed-meshheading:19450557... | lld:pubmed |
| pubmed-article:19450557 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19450557 | pubmed:articleTitle | Influence of TNF-alpha and biomechanical stress on endothelial anti- and prothrombotic genes. | lld:pubmed |
| pubmed-article:19450557 | pubmed:affiliation | Clinical Experimental Research Laboratory, Sahlgrenska University Hospital/Ostra, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. | lld:pubmed |
| pubmed-article:19450557 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19450557 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19450557 | lld:pubmed |
