Linked Life Data

19450458

Source:http://linkedlifedata.com/resource/pubmed/id/19450458

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-6-1
pubmed:abstractText
Previous studies have shown that Müller cells respond to excessive light with mislocalization of inwardly rectifying potassium channel (Kir4.1) and aquaporin-4 (AQP4) proteins. We investigated whether the retina is protected against light-induced damage in AQP4 knockout (KO) mice. KO and wildtype (WT) CD1 mice were exposed to 12h of intense white light (16 000+/-2000 lux) for six successive days. Electroretinograms (ERGs) were mildly affected in WT mice three days after light exposure, but returned to baseline on the seventh day following light exposure. In comparison, ERGs of KO mice were severely and irreversibly impaired after light exposure. Consistent with the ERG findings, light exposure had no effect on retinal structure in WT mice but reduced the thickness of both the outer and inner nuclear layers in KO mice. These findings indicate that loss of AQP4 renders the retina more susceptible to light-induced retinal degeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1096-0007
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-22
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Increased sensitivity to retinal light damage in aquaporin-4 knockout mice.
pubmed:publicationType
Letter, Research Support, Non-U.S. Gov't