19450275

Source:http://linkedlifedata.com/resource/pubmed/id/19450275

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0022131, umls-concept:C0034693, umls-concept:C0034721, umls-concept:C0442335, umls-concept:C1160185, umls-concept:C1564874
pubmed:dateCreated	2009-5-28
pubmed:abstractText	Pancreatic islet transplantation is a promising treatment for type I diabetes mellitus, but current immunosuppressive strategies do not consistently provide long-term survival of transplanted islets. We are therefore investigating the use of adeno-associated viruses (AAVs) as gene therapy vectors to transduce rat islets with immunosuppressive genes prior to transplantation into diabetic mice.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101231645
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:issn	1743-422X
pubmed:author	pubmed-author:Blanchette-MackieE JoanEJ, pubmed-author:ChioriniJohn AJA, pubmed-author:CraigAnthony TAT, pubmed-author:DwyerNancy KNK, pubmed-author:GavrilovaOksanaO, pubmed-author:HarlanDavid MDM, pubmed-author:JouWilliamW, pubmed-author:LiuEricE, pubmed-author:McAlisterVictor JVJ, pubmed-author:OwensRoland ARA, pubmed-author:PackStephanieS, pubmed-author:PechholdKlausK, pubmed-author:SchmidtMichaelM
pubmed:issnType	Electronic
pubmed:volume	6
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	61
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:19450275-Animals, pubmed-meshheading:19450275-Cell Line, pubmed-meshheading:19450275-Dependovirus, pubmed-meshheading:19450275-Diabetes Mellitus, Type 1, pubmed-meshheading:19450275-Female, pubmed-meshheading:19450275-Gene Therapy, pubmed-meshheading:19450275-Genetic Vectors, pubmed-meshheading:19450275-Humans, pubmed-meshheading:19450275-Islets of Langerhans, pubmed-meshheading:19450275-Islets of Langerhans Transplantation, pubmed-meshheading:19450275-Mice, pubmed-meshheading:19450275-Mice, Inbred NOD, pubmed-meshheading:19450275-Mice, SCID, pubmed-meshheading:19450275-Rats, pubmed-meshheading:19450275-Rats, Wistar, pubmed-meshheading:19450275-Transduction, Genetic
pubmed:year	2009
pubmed:articleTitle	Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.
pubmed:affiliation	Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. anthonycraig3@gmail.com
pubmed:publicationType	Journal Article, In Vitro, Evaluation Studies, Research Support, N.I.H., Intramural