Linked Life Data

19449316

Source:http://linkedlifedata.com/resource/pubmed/id/19449316

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-7-2
pubmed:abstractText
The development of nervous system connectivity depends upon the arborization of dendritic fields and the stabilization of dendritic spine synapses. It is well established that neuronal activity and the neurotrophin BDNF modulate these correlated processes. However, the downstream mechanisms by which these extrinsic signals regulate dendritic development and spine stabilization are less well known. Here we report that a substrate of BDNF signaling, the Ankyrin Repeat-rich Membrane Spanning (ARMS) protein or Kidins220, plays a critical role in the branching of cortical and hippocampal dendrites and in the turnover of cortical spines. In the barrel somatosensory cortex and the dentate gyrus, regions where ARMS/Kidins220 is highly expressed, no difference in the complexity of dendritic arbors was observed in 1-month-old adolescent ARMS/Kidins220(+/-) mice compared to wild-type littermates. However, at 3 months of age, young adult ARMS/Kidins220(+/-) mice exhibited decreased dendritic complexity. This suggests that ARMS/Kidins220 does not play a significant role in the initial formation of dendrites but, rather, is involved in the refinement or stabilization of the arbors later in development. In addition, at 1 month of age, the rate of spine elimination was higher in ARMS/Kidins220(+/-) mice than in wild-type mice, suggesting that ARMS/Kidins220(+/-) levels regulate spine stability. Taken together, these data suggest that ARMS/Kidins220 is important for the growth of dendritic arbors and spine stability during an activity- and BDNF-dependent period of development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1932-8451
pubmed:author
pubmed:copyrightInfo
(c) 2009 Wiley Periodicals, Inc. Develop Neurobiol 2009.
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
547-57
pubmed:dateRevised
2011-4-28
pubmed:meshHeading
pubmed-meshheading:19449316-Age Factors, pubmed-meshheading:19449316-Animals, pubmed-meshheading:19449316-Ankyrin Repeat, pubmed-meshheading:19449316-Brain-Derived Neurotrophic Factor, pubmed-meshheading:19449316-Cells, Cultured, pubmed-meshheading:19449316-Cerebral Cortex, pubmed-meshheading:19449316-Dendritic Spines, pubmed-meshheading:19449316-Embryo, Mammalian, pubmed-meshheading:19449316-Female, pubmed-meshheading:19449316-Gene Expression Regulation, Developmental, pubmed-meshheading:19449316-Hippocampus, pubmed-meshheading:19449316-Luminescent Proteins, pubmed-meshheading:19449316-Male, pubmed-meshheading:19449316-Membrane Proteins, pubmed-meshheading:19449316-Mice, pubmed-meshheading:19449316-Mice, Inbred C57BL, pubmed-meshheading:19449316-Mice, Transgenic, pubmed-meshheading:19449316-Microtubule-Associated Proteins, pubmed-meshheading:19449316-Mutation, pubmed-meshheading:19449316-Neurites, pubmed-meshheading:19449316-Neurons, pubmed-meshheading:19449316-Rats, pubmed-meshheading:19449316-Rats, Sprague-Dawley, pubmed-meshheading:19449316-Silver Staining
pubmed:year
2009
pubmed:articleTitle
Ankyrin Repeat-rich Membrane Spanning/Kidins220 protein regulates dendritic branching and spine stability in vivo.
pubmed:affiliation
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural