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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-7-17
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pubmed:abstractText |
Hypoxia-inducible factor-1 (HIF-1) is the key regulator of cellular responses to hypoxia and presumably plays a central role in the control of tumor growth. Polymorphisms or mutations increasing its activity and stability in vitro under normoxia have recently been identified. In this study, we aimed to investigate the effect of C1772T and G1790A single nucleotide polymorphisms (SNPs), located within the exon 12 of HIF-1alpha on the prognosis of early stages of oral squamous cell carcinoma (OSCC).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1534-4681
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2351-8
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pubmed:meshHeading |
pubmed-meshheading:19449077-Adolescent,
pubmed-meshheading:19449077-Adult,
pubmed-meshheading:19449077-Aged,
pubmed-meshheading:19449077-Aged, 80 and over,
pubmed-meshheading:19449077-Carcinoma, Squamous Cell,
pubmed-meshheading:19449077-Case-Control Studies,
pubmed-meshheading:19449077-Female,
pubmed-meshheading:19449077-Genotype,
pubmed-meshheading:19449077-Humans,
pubmed-meshheading:19449077-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:19449077-Lymphatic Metastasis,
pubmed-meshheading:19449077-Male,
pubmed-meshheading:19449077-Middle Aged,
pubmed-meshheading:19449077-Mouth Neoplasms,
pubmed-meshheading:19449077-Neoplasm Staging,
pubmed-meshheading:19449077-Polymerase Chain Reaction,
pubmed-meshheading:19449077-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:19449077-Polymorphism, Single Nucleotide,
pubmed-meshheading:19449077-Prognosis,
pubmed-meshheading:19449077-Survival Rate,
pubmed-meshheading:19449077-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Polymorphisms in the hypoxia inducible factor 1-alpha and the impact on the prognosis of early stages of oral cancer.
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pubmed:affiliation |
Department of Oral & Maxillofacial Surgery, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain. maxmferm@excite.com
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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