Linked Life Data

19447662

Source:http://linkedlifedata.com/resource/pubmed/id/19447662

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-6-15
pubmed:abstractText
Familial clustering of a disease in the absence of a definite Mendelian determination is not an uncommon observation. Complex multigenic systems, variable penetrance, environmental factors, as well as other ad hoc explanations are commonly invoked. On the other hand, experimental models recently generated in the mouse lead to the alternative, non-exclusive concept of the transgenerational maintenance of a pathogenic epigenetic variation. Thus, we recently identified a new mode of epigenetic inheritance mediated by RNA and micro-RNA which is released by sperm. This discovery, namely that RNA molecules present in the spermatozoon head may be possible vectors for the hereditary transfer of epigenetic modifications, may have both fundamental and medical interests.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1297-9589
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
558-61
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Epigenetic inheritance of the sperm: an unexpected role of RNA].
pubmed:affiliation
Inserm U636, université de Nice, parc Valrose, 06100 Nice, France. grandjea@unice.fr
pubmed:publicationType
Journal Article, English Abstract