Linked Life Data

19446056

Source:http://linkedlifedata.com/resource/pubmed/id/19446056

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-9-22
pubmed:abstractText
Appropriate porosity is an important biomaterial design criterion for scaffolds used in tissue engineering applications as it can permit increased cell adhesion, migration, proliferation and extracellular matrix production within the scaffold at a tissue defect site. Tissue engineering scaffolds can either be injected in a minimally invasive manner or implanted through surgical procedures. Many injectable scaffolds are hydrogel-based; these materials often possess nanoscale porosity, which is suboptimal for cell migration and proliferation. Solid scaffolds with engineered micron-scale porosity are widely used, but these scaffolds are usually pre-formed and then must be implanted. Here we report on the development of a solid, injectable, biomaterial scaffold that solidifies in situ via phase inversion with microporous, interconnected architecture on the surface and within the bulk. This injectable system utilizes the biodegradable polymer poly(lactic-co-glycolic acid), a nontoxic FDA-approved solvent, and biocompatible porogens. Various scaffold formulations are examined in terms of morphology, porosity, degradation, elastic modulus, and ability to support cellular adhesion and growth. Furthermore, the ability to form a microporous architecture upon injection in vivo is verified. This technology is a promising noninvasive approach for in vivo formation of porous biodegradable scaffolds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1878-7568
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2847-59
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Injectable poly(lactic-co-glycolic) acid scaffolds with in situ pore formation for tissue engineering.
pubmed:affiliation
Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't