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pubmed:abstractText |
Genetic disruption of an important phenotype should favor compensatory mutations that restore the phenotype. If the genetic basis of the phenotype is modular, with a network of interacting genes whose functions are specific to that phenotype, compensatory mutations are expected among the genes of the affected network. This perspective was tested in the bacteriophage T3 using a genome deleted of its DNA ligase gene, disrupting DNA metabolism.
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pubmed:affiliation |
Section of Integrative Biology, Institute for Cell and Molecular Biology, Center for Computational Biology and Bioinformatics, University of Texas, Austin, Texas 78712, USA. harcombe@mail.utexas.edu
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