Source:http://linkedlifedata.com/resource/pubmed/id/19444936
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2009-5-13
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pubmed:abstractText |
The metabolism of steroids at position 17 is catalysed by a growing number of 17beta-hydroxysteroid dehydrogenases (17beta-HSDs). Several human diseases like breast or prostate cancer, endometriosis,metabolic syndrome and mental diseases were associated with dysfunctions of 17beta-HSDs, which consequently became drug targets. This review will focus on identities of 17beta-HSDs and recent advances in analyses of their physiological roles in steroid and lipid metabolism. It will also address the potential of metabolomics in drug development.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1879-1220
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
72-7
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pubmed:dateRevised |
2009-6-8
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pubmed:meshHeading |
pubmed-meshheading:19444936-17-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:19444936-Animals,
pubmed-meshheading:19444936-Drug Design,
pubmed-meshheading:19444936-Humans,
pubmed-meshheading:19444936-Isoenzymes,
pubmed-meshheading:19444936-Lipid Metabolism,
pubmed-meshheading:19444936-Metabolomics,
pubmed-meshheading:19444936-Molecular Structure,
pubmed-meshheading:19444936-Steroids
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pubmed:year |
2009
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pubmed:articleTitle |
Recent advances in 17beta-hydroxysteroid dehydrogenases.
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pubmed:affiliation |
Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany.
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pubmed:publicationType |
Journal Article,
Review
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