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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-7-17
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pubmed:abstractText |
The Tec kinase Itk is critical for the development of alphabeta T cells as well as differentiation of CD4(+) T cells into Th2 cells. Itk null mice have defects in the production of Th2 cytokines; however, they paradoxically have significant elevations in serum IgE. Here we show that Itk null mice have increased numbers of gammadelta T cells in the thymus and spleen. This includes elevated numbers of CD4(+) gammadelta T cell, the majority of which carry the Vgamma1.1 and Vdelta6.2/3 gammadelta T-cell receptor with a distinct phenotype. The development of these CD4(+) gammadelta T cells is T cell intrinsic, independent of either major histocompatibility complex class I or class II, and is favored during development in the absence of Itk. Itk null CD4(+) gammadelta T cells secrete significant amounts of Th2 cytokines and can induce the secretion of IgE by wild-type B cells. Our data indicate that Itk plays important role in regulating gammadelta T-cell development and function. In addition, our data indicate that the elevated IgE observed in Itk-deficient mice is due in part to the enhanced development of CD4(+) gammadelta T cells in the absence of Itk.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-10549622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-10837080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-11395491,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-12970761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-14978091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-15084276,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-16547221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-16630934,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-2788280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-3486721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-7816142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-7869041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-7890430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-8642336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-9469460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19443662-9596580
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1528-0020
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
564-71
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pubmed:dateRevised |
2011-4-13
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pubmed:meshHeading |
pubmed-meshheading:19443662-Animals,
pubmed-meshheading:19443662-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19443662-Cell Proliferation,
pubmed-meshheading:19443662-Cytokines,
pubmed-meshheading:19443662-Immunoglobulin E,
pubmed-meshheading:19443662-Mice,
pubmed-meshheading:19443662-Mice, Knockout,
pubmed-meshheading:19443662-Protein-Tyrosine Kinases,
pubmed-meshheading:19443662-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:19443662-Spleen,
pubmed-meshheading:19443662-Th2 Cells,
pubmed-meshheading:19443662-Thymus Gland
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pubmed:year |
2009
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pubmed:articleTitle |
Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production.
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pubmed:affiliation |
Center for Molecular Immunology & Infectious Disease, Department of Veterinary & Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA. avery@psu.edu
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pubmed:publicationType |
Journal Article
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