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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0005684,
umls-concept:C0032529,
umls-concept:C0059735,
umls-concept:C0298987,
umls-concept:C0596244,
umls-concept:C0599755,
umls-concept:C0796518,
umls-concept:C0919425,
umls-concept:C0919451,
umls-concept:C1135159,
umls-concept:C1556084
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pubmed:issue |
5
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pubmed:dateCreated |
2009-5-15
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pubmed:abstractText |
Tobacco smoking and environmental exposures are the main known risk factors for bladder cancer (BC) via exposure to chemical carcinogens. Genetic differences in the metabolism of chemicals have been suggested to be associated with individual susceptibility to BC. Polymorphisms in genes coding to metabolising enzymes, resulting in variation of carcinogen detoxification efficiency, may therefore change the response of individuals to chemical carcinogens and be associated with an increased BC risk.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0250-7005
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pubmed:author |
pubmed-author:Bernard-GallonDominique JDJ,
pubmed-author:BignonYves-JeanYJ,
pubmed-author:BoiteuxJean-PaulJP,
pubmed-author:BosvielRemyR,
pubmed-author:ChamouxAlainA,
pubmed-author:DelortLaetitiaL,
pubmed-author:FontanaLucL,
pubmed-author:GuyLaurentL,
pubmed-author:JoumardLaurieL,
pubmed-author:LuiAmyA,
pubmed-author:RabiauNadegeN
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1631-5
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pubmed:dateRevised |
2010-9-8
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pubmed:meshHeading |
pubmed-meshheading:19443378-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:19443378-Arylamine N-Acetyltransferase,
pubmed-meshheading:19443378-Base Sequence,
pubmed-meshheading:19443378-Case-Control Studies,
pubmed-meshheading:19443378-Catechol O-Methyltransferase,
pubmed-meshheading:19443378-Cohort Studies,
pubmed-meshheading:19443378-Cytochrome P-450 CYP1A1,
pubmed-meshheading:19443378-DNA Primers,
pubmed-meshheading:19443378-Genetic Predisposition to Disease,
pubmed-meshheading:19443378-Glutathione Transferase,
pubmed-meshheading:19443378-Humans,
pubmed-meshheading:19443378-Male,
pubmed-meshheading:19443378-Polymorphism, Single Nucleotide,
pubmed-meshheading:19443378-Urinary Bladder Neoplasms
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pubmed:year |
2009
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pubmed:articleTitle |
Genetic polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 genes and association with bladder cancer risk in a French cohort.
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pubmed:affiliation |
Université Clermont 1, Faculté de Médecine, 28 place Henri Dunant, 63001 Clermont-Ferrand Cedex 01 France. Luc.fontana@u-clermont1.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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