Linked Life Data

19442737

Source:http://linkedlifedata.com/resource/pubmed/id/19442737

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pubmed-article:19442737pubmed:abstractTextTwo brain disease-related genes, one coding for the protease inhibitor SERPINI1 which is down-regulated in brain tumors, and the other for the PDCD10 programmed cell death gene which is often mutated in cerebral cavernous malformation, are closely adjacent in a head-to-head configuration and separated by only 851 bp on human chromosome 3q26. The 851-bp intergenic region contains a GC-rich 175-bp minimal bidirectional promoter which is essential for transcriptional activation of the two flanking genes. The oncogenic c-Myc transcription factor was identified to bind to a non-canonical E-box element (5'-CATGCG-3') of the minimal bidirectional promoter to drive both gene expressions. Methylation at the specific C nucleotide within the E-box sequence (5'-CATG(m)CG-3'), however, would severely interfere with the binding of c-Myc to the E-box. These results suggest that c-Myc plays an important role in regulating the coordinated transcription of the PDCD10-SERPINI1 bidirectional gene pair, and is possibly involved in differential expressions of these two neighboring genes in central nervous system diseases such as brain cancer.lld:pubmed
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pubmed-article:19442737pubmed:authorpubmed-author:WuCheng-WenCWlld:pubmed
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pubmed-article:19442737pubmed:articleTitlec-Myc regulates the coordinated transcription of brain disease-related PDCD10-SERPINI1 bidirectional gene pair.lld:pubmed
pubmed-article:19442737pubmed:affiliationNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan, ROC.lld:pubmed
pubmed-article:19442737pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19442737pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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