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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-7-28
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pubmed:abstractText |
Two brain disease-related genes, one coding for the protease inhibitor SERPINI1 which is down-regulated in brain tumors, and the other for the PDCD10 programmed cell death gene which is often mutated in cerebral cavernous malformation, are closely adjacent in a head-to-head configuration and separated by only 851 bp on human chromosome 3q26. The 851-bp intergenic region contains a GC-rich 175-bp minimal bidirectional promoter which is essential for transcriptional activation of the two flanking genes. The oncogenic c-Myc transcription factor was identified to bind to a non-canonical E-box element (5'-CATGCG-3') of the minimal bidirectional promoter to drive both gene expressions. Methylation at the specific C nucleotide within the E-box sequence (5'-CATG(m)CG-3'), however, would severely interfere with the binding of c-Myc to the E-box. These results suggest that c-Myc plays an important role in regulating the coordinated transcription of the PDCD10-SERPINI1 bidirectional gene pair, and is possibly involved in differential expressions of these two neighboring genes in central nervous system diseases such as brain cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Azacitidine,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/MYC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/Serpins,
http://linkedlifedata.com/resource/pubmed/chemical/decitabine,
http://linkedlifedata.com/resource/pubmed/chemical/neuroserpin
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1095-9327
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
23-32
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pubmed:meshHeading |
pubmed-meshheading:19442737-Apoptosis Regulatory Proteins,
pubmed-meshheading:19442737-Azacitidine,
pubmed-meshheading:19442737-Cell Line, Tumor,
pubmed-meshheading:19442737-Chromatin Immunoprecipitation,
pubmed-meshheading:19442737-DNA Methylation,
pubmed-meshheading:19442737-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:19442737-Enzyme Inhibitors,
pubmed-meshheading:19442737-Glioblastoma,
pubmed-meshheading:19442737-Humans,
pubmed-meshheading:19442737-Membrane Proteins,
pubmed-meshheading:19442737-Molecular Sequence Data,
pubmed-meshheading:19442737-Mutagenesis, Site-Directed,
pubmed-meshheading:19442737-Neuroblastoma,
pubmed-meshheading:19442737-Neuropeptides,
pubmed-meshheading:19442737-Promoter Regions, Genetic,
pubmed-meshheading:19442737-Proto-Oncogene Proteins,
pubmed-meshheading:19442737-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:19442737-Serpins,
pubmed-meshheading:19442737-Transcriptional Activation
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pubmed:year |
2009
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pubmed:articleTitle |
c-Myc regulates the coordinated transcription of brain disease-related PDCD10-SERPINI1 bidirectional gene pair.
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pubmed:affiliation |
National Institute of Cancer Research, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan, ROC.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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