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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-6-2
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pubmed:abstractText |
The 19 kDa lipoprotein of Mycobacterium tuberculosis (MTB) is an important target of the innate immune response. To investigate the effect of post-translation modification of this protein on innate recognition in the context of the whole bacillus, we derived a recombinant M. tuberculosis H37Rv that lacked the 19 kDa gene (Delta19) and complemented this strain by reintroduction of the 19 kDa gene into the chromosome as a single copy to produce Delta19::19. We also reintroduced the 19 kDa gene in two modified forms that lacked motifs for acylation (Delta19::19NA) and O-glycosylation (Delta19::19NOG).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19442300-10426995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19442300-10577507,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19442300-12524386,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2180
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93
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pubmed:dateRevised |
2010-1-11
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pubmed:meshHeading |
pubmed-meshheading:19442300-Acylation,
pubmed-meshheading:19442300-Amino Acid Sequence,
pubmed-meshheading:19442300-Antigens, Bacterial,
pubmed-meshheading:19442300-Apoptosis,
pubmed-meshheading:19442300-Cells, Cultured,
pubmed-meshheading:19442300-Cloning, Molecular,
pubmed-meshheading:19442300-Cytokines,
pubmed-meshheading:19442300-Databases, Protein,
pubmed-meshheading:19442300-Gene Deletion,
pubmed-meshheading:19442300-Glycosylation,
pubmed-meshheading:19442300-Humans,
pubmed-meshheading:19442300-Immunity, Innate,
pubmed-meshheading:19442300-Lipoproteins,
pubmed-meshheading:19442300-Molecular Sequence Data,
pubmed-meshheading:19442300-Monocytes,
pubmed-meshheading:19442300-Mutation,
pubmed-meshheading:19442300-Mycobacterium tuberculosis,
pubmed-meshheading:19442300-Protein Processing, Post-Translational,
pubmed-meshheading:19442300-Sequence Alignment,
pubmed-meshheading:19442300-Statistics, Nonparametric
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pubmed:year |
2009
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pubmed:articleTitle |
Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis.
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pubmed:affiliation |
National Institute for Medical Research, Mill Hill, London, UK. katalin.wilkinson@uct.ac.za
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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