Linked Life Data

19440149

Source:http://linkedlifedata.com/resource/pubmed/id/19440149

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-7-1
pubmed:abstractText
1-(2,4-dimethoxyphenyl)-3-(1-methylindolyl) propenone, namely IPP51, was identified by screening a library of 3-indolyl-1-phenylpropenones. IPP51 was investigated for its ability to inhibit proliferation and/or to induce apoptosis of human bladder cancer cell lines and to assess its potential use in bladder carcinoma treatment. After treating the cells with IPP51 for 24 h, the title compound induced a predominant and reversible G2+M accumulation at the prometaphase stage of mitosis. However, when used for a longer period, it leads to cell apoptosis. These results suggest that the compound has potential anticancer activities, which could be useful in bladder cancer treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1473-5741
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
469-76
pubmed:dateRevised
2010-1-13
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Investigation of a new 1,3-diarylpropenone as a potential antimitotic agent targeting bladder carcinoma.
pubmed:affiliation
Laboratoire de Dynamique Cellulaire, EPHE, Laboratoire TIMC-IMAG, UMR CNRS 5525, Université Joseph Fourier, La Tronche, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't