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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-9-17
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pubmed:abstractText |
Secretory phospholipases A(2) (sPLA(2)) are an emerging class of mediators of inflammation. These enzymes are released in vivo in patients with systemic inflammatory diseases and allergic disorders. sPLA(2)s may activate inflammatory cells by both enzymatic and nonenzymatic mechanisms. The aim of this study was to evaluate the effect of the inhaled glucocorticoid budesonide on sPLA(2)-induced activation of primary human macrophages.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Budesonide,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Dactinomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronidase,
http://linkedlifedata.com/resource/pubmed/chemical/Group IA Phospholipases A2,
http://linkedlifedata.com/resource/pubmed/chemical/Group X Phospholipases A2,
http://linkedlifedata.com/resource/pubmed/chemical/IL6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A2, Secretory,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0097
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2009 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
144-55
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19439980-Arachidonic Acid,
pubmed-meshheading:19439980-Budesonide,
pubmed-meshheading:19439980-Cycloheximide,
pubmed-meshheading:19439980-Cytokines,
pubmed-meshheading:19439980-Dactinomycin,
pubmed-meshheading:19439980-Gene Expression,
pubmed-meshheading:19439980-Glucuronidase,
pubmed-meshheading:19439980-Group IA Phospholipases A2,
pubmed-meshheading:19439980-Group X Phospholipases A2,
pubmed-meshheading:19439980-Humans,
pubmed-meshheading:19439980-Interleukin-6,
pubmed-meshheading:19439980-Interleukin-8,
pubmed-meshheading:19439980-Macrophages, Alveolar,
pubmed-meshheading:19439980-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:19439980-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:19439980-Phospholipases A2, Secretory,
pubmed-meshheading:19439980-Phosphorylation,
pubmed-meshheading:19439980-Protein Kinase Inhibitors,
pubmed-meshheading:19439980-Signal Transduction,
pubmed-meshheading:19439980-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19439980-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
Inhibition of secretory phospholipase A2-induced cytokine production in human lung macrophages by budesonide.
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pubmed:affiliation |
Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy. triggian@unina.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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