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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2009-5-14
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pubmed:abstractText |
Variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been associated with heightened neural activity in limbic and prefrontal regions in response to emotional stimuli. The current study examined whether the 5-HTTLPR polymorphism is also associated with alterations in microstructure of frontal-limbic white matter (WM) tracts. Thirty-seven (mean age, 20.51 years; range, 13-28) female participants were genotyped for the 5-HTTLPR polymorphism. Diffusion MRI was collected and a probabilistically defined tract of the uncinate fasciculus (UF), a WM pathway connecting the amygdala to medial and orbital prefrontal cortex, was used to generate fractional anisotropy (FA) values for participants. Regression analyses indicated a significant inverse association between number of low-expressing 5-HTTLPR alleles and FA values for the left frontal UF region, beta = - 0.42, p = 0.005. Furthermore, there was a positive association between age and FA values for bilateral frontal regions of the UF; these effects explained 39 and 20% of the variance in FA values for left and right frontal regions, respectively. 5-HTTLPR genotype and age appear to independently influence the WM microstructure of the UF. The observed reduction in FA values among low-expressing 5-HTTLPR allele carriers may contribute to biased regulation of emotional stimuli.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-11063977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-14587019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-15241435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-15654286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-15699291,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-1637966,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-16624579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-16642437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-17070705,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-17949693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-18024182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-18258310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-18271863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-18772028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-19710299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-2463275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-2898042,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19439600-9505045
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1529-2401
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6229-33
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:19439600-Adolescent,
pubmed-meshheading:19439600-Adult,
pubmed-meshheading:19439600-Aging,
pubmed-meshheading:19439600-Alleles,
pubmed-meshheading:19439600-Amygdala,
pubmed-meshheading:19439600-Anisotropy,
pubmed-meshheading:19439600-Continental Population Groups,
pubmed-meshheading:19439600-Diffusion Magnetic Resonance Imaging,
pubmed-meshheading:19439600-Ethnic Groups,
pubmed-meshheading:19439600-Female,
pubmed-meshheading:19439600-Functional Laterality,
pubmed-meshheading:19439600-Genotype,
pubmed-meshheading:19439600-Humans,
pubmed-meshheading:19439600-Neural Pathways,
pubmed-meshheading:19439600-Polymorphism, Single Nucleotide,
pubmed-meshheading:19439600-Prefrontal Cortex,
pubmed-meshheading:19439600-Promoter Regions, Genetic,
pubmed-meshheading:19439600-Regression Analysis,
pubmed-meshheading:19439600-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:19439600-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism.
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pubmed:affiliation |
Department of Psychology, The University of Texas at Austin, Austin, Texas 78712, USA. jpacheco@mail.utexas.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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