|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2009-5-25
|
|
pubmed:abstractText |
The neural crest generates multiple cell types during embryogenesis but the mechanisms regulating neural crest cell diversification are incompletely understood. Previous studies using mutant zebrafish indicated that foxd3 and tfap2a function early and differentially in the development of neural crest sublineages. Here, we show that the simultaneous loss of foxd3 and tfap2a function in zebrafish foxd3(zdf10);tfap2a(low) double mutant embryos globally prevents the specification of developmentally distinct neural crest sublineages. By contrast, neural crest induction occurs independently of foxd3 and tfap2a function. We show that the failure of neural crest cell diversification in double mutants is accompanied by the absence of neural crest sox10 and sox9a/b gene expression, and that forced expression of sox10 and sox9a/b differentially rescues neural crest sublineage specification and derivative differentiation. These results demonstrate the functional necessity for foxd3 and tfap2a for neural crest sublineage specification and that this requirement is mediated by the synergistic regulation of the expression of SoxE family genes. Our results identify a genetic regulatory pathway functionally discrete from the process of neural crest induction that is required for the initiation of neural crest cell diversification during embryonic development.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-10433906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-10508880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-10631172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-10751183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-10821756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-11071756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-11262245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-11335115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-11371614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-11493569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-11684650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-11684651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-11932942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-12381664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-12736222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-12783851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-12878728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-14523379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-14534133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-14697367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-14985255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-15689370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-15691760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-15817223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-16499899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-16510505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-16899407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-17008447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-17013879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-17065232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-18369445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-18508863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-1908772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-7607084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-7813774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-7911517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-8162850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-8306883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-8343963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-8589427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-8622765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-8622766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-8885715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-9334283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-9425902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-9499424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-9560246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-9576828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439494-9808777
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/SOX9 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sox9a protein, zebrafish,
http://linkedlifedata.com/resource/pubmed/chemical/Sox9b protein, zebrafish,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-2,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/foxd3 protein, zebrafish,
http://linkedlifedata.com/resource/pubmed/chemical/tfap2a protein, zebrafish
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0950-1991
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
136
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1987-94
|
|
pubmed:dateRevised |
2010-9-24
|
|
pubmed:meshHeading |
pubmed-meshheading:19439494-Animals,
pubmed-meshheading:19439494-Cell Lineage,
pubmed-meshheading:19439494-Embryo, Nonmammalian,
pubmed-meshheading:19439494-Forkhead Transcription Factors,
pubmed-meshheading:19439494-Gene Expression Regulation, Developmental,
pubmed-meshheading:19439494-Mutation,
pubmed-meshheading:19439494-Neural Crest,
pubmed-meshheading:19439494-SOX9 Transcription Factor,
pubmed-meshheading:19439494-Transcription Factor AP-2,
pubmed-meshheading:19439494-Zebrafish,
pubmed-meshheading:19439494-Zebrafish Proteins
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Genetic ablation of neural crest cell diversification.
|
|
pubmed:affiliation |
Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
